EIF3K
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Official Full Name
eukaryotic translation initiation factor 3, subunit K -
Overview
The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits,;including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and;promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 (PubMed 14519125)). -
Synonyms
EIF3K;eukaryotic translation initiation factor 3, subunit K;EIF3S12, eukaryotic translation initiation factor 3, subunit 12;eukaryotic translation initiation factor 3 subunit K;ARG134;HSPC029;M9;PLAC 24;PRO1474;PTD001;eIF-3 p25;eIF-3 p2
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- Insect Cell
- E. coli
- HEK293
- Insect Cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- N-Twin strep and C-His&Flag
- His&Fc&Avi
- His&GST
- Myc&DDK
Involved Pathway
EIF3K involved in several pathways and played different roles in them. We selected most pathways EIF3K participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Cap-dependent Translation Initiation,Eukaryotic Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF3K were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of a pool of free 40S subunits | EIF1AXA,FAUB,EIF1AX,RPL35 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | EIF1AXA,EIF2S3,RPL35,EIF4B,EIF4A2,EIF4H,EIF1AX,FAUB,EIF2S1A,EIF4A1 |
| Formation of the ternary complex, and subsequently, the 43S complex | EIF2S3,EIF1AX,EIF2S1,EIF2S1A,FAUB,EIF1AXA |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF1AXA,EIF2S1,EIF4G1,EIF4H,EIF2S1A,EIF1AX,EIF2S3,EIF4B,EIF4A1,EIF4EBP1 |
| Gene Expression | SETB,ZNF471,IGF2BP2,ZNF621,ZNF791,SF3B2,MBD3,ZNF205,NR2E3,ZNF668 |
| Cap-dependent Translation Initiation | EIF4B,EIF1AXA,EIF4EB,EIF4A1,EIF2S1,EIF2B1,EIF4G1,EIF4E,EIF2S1A,EIF4EBP1 |
| L13a-mediated translational silencing of Ceruloplasmin expression | EIF2S3,EIF1AXA,EIF1AX,EIF2S1A,FAUB,EIF4H |
| Eukaryotic Translation Initiation | FAUB,EIF2S1,EIF4A2,RPL35,EIF4A1,EIF4B,EIF4EB,EIF2S3,EIF5,EIF1AX |
Protein Function
EIF3K has several biochemical functions, for example, RNA binding,ribosome binding,contributes_to translation initiation factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF3K itself. We selected most functions EIF3K had, and list some proteins which have the same functions with EIF3K. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribosome binding | CPEB2,HSPA5,RICTOR,ETF1B,RPN2,EIF6,ICT1,ABCF1,OLA1,MTRF1L |
| contributes_to translation initiation factor activity | EIF3J,EIF3BA,EIF3EA,EIF3EB,EIF3HB,EIF3F,EIF3G,EIF3S6IP,EIF2B3,EIF3H |
| RNA binding | APOBEC2,SFPI1,RPL34,CPEB1B,RNASEL3,RPS7,HNRNPD,YTHDC1,CAPRIN1,UPF1 |
Interacting Protein
EIF3K has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF3K here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF3K.
Eif3a;Ywhae
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