EIF2S2
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Official Full Name
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -
Overview
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. -
Synonyms
EIF2S2;eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa;EIF2, eukaryotic translation initiation factor 2, subunit 2 (beta, 38kD );eukaryotic translation initiation factor 2 subunit 2;EIF2beta;PPP1R67;protein phosphatase 1;regulato
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- E.coli
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
EIF2S2 involved in several pathways and played different roles in them. We selected most pathways EIF2S2 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2S2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | TRNT1,RANGAP1,SNUPN,EIF4EBP3L,TPR,EIF3EA,EIF4BB,EIF2B5,SUMO1,DDX39B |
Protein Function
EIF2S2 has several biochemical functions, for example, RNA binding,metal ion binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2S2 itself. We selected most functions EIF2S2 had, and list some proteins which have the same functions with EIF2S2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | RPS9,DKC1,RPL13A,KCTD12,C11orf68,SAMSN1,DHX29,TFB2M,SFRS9,MYEF2 |
| protein binding | PDCD5,BCL2A1A,ATP6V1G1,STMN1,DZIP1L,TNIP3,GNB2,TNFSF10,NFAT5,TEX19.1 |
| translation factor activity, RNA binding | PPP1R2P9,EIF5,GTF2H3,EIF1,GTF2H2,EIF4G1,EIF4G3,CPEB1A,CPEB1B,MTIF3 |
| translation initiation factor activity | GTPBP2,EIF3BA,EIF4A1A,EIF1B,EIF1AXB,EIF2D,EIF4EB,EIF2S1,GTPBP1,DHX29 |
| RNA binding | RBM12B2,MRPL12,PTBP2A,EIF5A,SAMD4,MARF1,PPP5C,OASL1,CWC15,SYNCRIP |
| metal ion binding | ZNRF2B,ALDH1A2,ARSD,AURKB,TRIM43B,IKZF1,INSM1B,COX4I2,MTMR3,NR2F1A |
Interacting Protein
EIF2S2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2S2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2S2.
EIF2S1;EIF4G2;EIF2S3;CSNK2A1;EIF2B2;oks16_human;TP53;APLP1;TLE1;ZBTB16
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References
- Gatza, ML; Silva, GO; et al. An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer. NATURE GENETICS 46:1051-1059(2014).
- Heaney, JD; Michelson, MV; et al. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. HUMAN MOLECULAR GENETICS 18:1395-1404(2009).
