EIF2B3
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Official Full Name
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -
Overview
The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] -
Synonyms
EIF2B3;eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa;EIF-2B;EIF2Bgamma;translation initiation factor eIF-2B subunit gamma;eIF-2B GDP-GTP exchange factor subunit gamma
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
EIF2B3 involved in several pathways and played different roles in them. We selected most pathways EIF2B3 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | CYFIP1,EIF3BA,DDX39B,RPP14,ELAC2,PAIP1,RPP40,POM121L2,SNUPN,EIF2S2 |
Protein Function
EIF2B3 has several biochemical functions, for example, NOT S-methyl-5-thioribose-1-phosphate isomerase activity,contributes_to guanyl-nucleotide exchange factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B3 itself. We selected most functions EIF2B3 had, and list some proteins which have the same functions with EIF2B3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | WWP2,FKBPL,ANG,MNDA,PRR13,FASTKD3,CEP120,SREK1,ACSS1,SUCLA2 |
| contributes_to guanyl-nucleotide exchange factor activity | C7orf59,EIF2B5,LAMTOR3,LAMTOR1,LAMTOR2,EIF2B2,ALS2,EIF2B1,HBXIP,EIF2B4 |
| contributes_to translation initiation factor activity | EIF3L,EIF3M,EIF2B5,EIF3HA,EIF3J,EIF2B4,EIF3S10,EIF3E,EIF3D,EIF3G |
| NOT S-methyl-5-thioribose-1-phosphate isomerase activity | EIF2B2,EIF2B1,EIF2B4 |
| translation initiation factor binding | DDX3X,EIF3M,POLR2G,ZNF259,LIN28A,EIF3BA,POLR2D,POLR2GL,EIF2B5,RPS24 |
Interacting Protein
EIF2B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B3.
EIF2B1;STC2;NDUFB8;GOLM1;pi3p;ZWINT;EGFR;Cdk1;NSS;CDC42
Resources
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References
- Robinson, ME; Rossignol, E; et al. Vanishing White Matter Disease in French-Canadian Patients From Quebec. PEDIATRIC NEUROLOGY 51:225-232(2014).
- Wan, JY; Edwards, KL; et al. Association mapping of the PARK10 region for Parkinson's disease susceptibility genes. PARKINSONISM & RELATED DISORDERS 20:93-98(2014).
