EIF2AK3
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Official Full Name
eukaryotic translation initiation factor 2-alpha kinase 3 -
Overview
PERK (PKR-like ER kinase) is a single-pass type I ER membrane protein with a stress-sensing luminal domain connected by a transmembrane segment to a cytoplasmic-kinase domain. -
Synonyms
EIF2AK3;eukaryotic translation initiation factor 2-alpha kinase 3;PEK;PERK;hsPEK;pancreatic EIF2-alpha kinase;PRKR-like endoplasmic reticulum kinase;eukaryotic translation initiation factor 2 alpha kinase 3;WRS;DKFZp781H1925
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- Mammalian cells
- HEK293T
- GST
- His&T7
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
EIF2AK3 involved in several pathways and played different roles in them. We selected most pathways EIF2AK3 participated on our site, such as Protein processing in endoplasmic reticulum,Non-alcoholic fatty liver disease (NAFLD),Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Influenza A | IL6,OAS3,IFNA3,IFNA6,MAP2K6,PABPN1L,FAS,LOC780933,TLR3,MX1 |
| Herpes simplex infection | C5,TRP53,DAXX,Casp3,PPP1CAA,ABCB3L1,SRSF2A,CLOCKA,SFRS3B,SKP1 |
| Non-alcoholic fatty liver disease (NAFLD) | ADIPOQ,IRS1,NDUFC2-KCTD14,IRS2,PKLR,NDUFV1,Casp3,PIK3R5,MAPK8,ADIPOR1 |
| Protein processing in endoplasmic reticulum | UGGT1,UBE2G1,RAD23A,EDEM2,STT3B,PDIP5,DNAJC5GA,FBXO6,HSPBP1,RRBP1A |
| Alzheimers disease | NDUFC2-KCTD14,PPP3CA,COX7A2,CALM2,NDUFA8,ADAM10,NDUFS7,GRIN1,ERN1,PSEN2 |
| Hepatitis C | NRAS,OAS3,TRAF6,CLDN2,BRAF,PDPK1,IFNA8,TNFRSF1A,MAVS,PIK3CB |
| Epstein-Barr virus infection | HLA-C,IL10RB,RB1,PLCG2,PSMC3,POLR3C,TAB1,YWHAH,MAP3K14,LYN |
| Measles | IL4,IL13,TNFAIP3,IFNGR1,HSPA8,IFNAR2,PIK3R1,CCND3,TLR4,AKT1 |
Protein Function
EIF2AK3 has several biochemical functions, for example, ATP binding,Hsp90 protein binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK3 itself. We selected most functions EIF2AK3 had, and list some proteins which have the same functions with EIF2AK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Hsp90 protein binding | USP19,UNC45A,CSNK2A1,RPS3,UNC45B,PPID,NASP,HDAC6,GBP1,FKBP6 |
| ATP binding | MAPK4,NSF,PRKD1,CDK1,GART,MYO1G,VPS4A,ADCY7,FIGNL2,HIPK1 |
| protein phosphatase binding | STAT3,CDH5,ANAPC7,Itga10&Itgb1,DRD1,PPP6R1,FLT4,ITGA1,MAP2K7,PIK3R2 |
| protein binding | APOB,VHLL,SLX1B,EMP3,PRKX,MAGEA9,SNF8,CLIC2,FGF1,PAFAH1B1 |
| enzyme binding | DDC,TSPYL1,JUND,UGT1A2,TRIO,CBS,A2M,CYP1A1,PRKCD,PRKCH |
| identical protein binding | RIPK1,GRIK5,ACY3,CSNK2B,TRA@,LZTFL1,CBY1,ITGA2B,UAP1,CLDN20 |
| protein serine/threonine kinase activity | DCLK1A,SNRKB,MAST2,SGK3,NUAK1,NEK1,SLKA,MYLK4,MELK,AKT3 |
| protein homodimerization activity | SNX1,CEBPB,TMEM173,GDNFA,INHBB,SLIT2,MTPAP,TP53I3,TLR13,PYGB |
| protein kinase activity | CCL5,ERBB3B,ARAF,CLK2B,PLK1,PKDCC,STK4,CSNK1G2A,AKT3A,RIPK1 |
Interacting Protein
EIF2AK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK3.
HSPA5;HSP90B1;aroE;BCL6
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