EIF2AK1
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Official Full Name
eukaryotic translation initiation factor 2-alpha kinase 1 -
Overview
The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] -
Synonyms
EIF2AK1;eukaryotic translation initiation factor 2-alpha kinase 1;HCR;HRI;heme-regulated inhibitor;heme-regulated repressor;heme-controlled repressor;heme sensitive initiation factor 2a kinase;heme regulated initiation factor 2 alpha kinase;heme-regulated initiation factor 2-alpha kinase;hemin-sensitive initiation factor 2-alpha kinase;heme-regulated eukaryotic initiation factor eIF-2-alpha kinase
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Cynomolgus
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- Sf9 Insect Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&GST
- His&Fc&Avi
Involved Pathway
EIF2AK1 involved in several pathways and played different roles in them. We selected most pathways EIF2AK1 participated on our site, such as Protein processing in endoplasmic reticulum,Hepatitis C,Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis C | IFNA7,IFNA14,NR1H3,IFNAR1,ARAF,BRAF,CLDN23,MAPK3,CLDN11,IFNA6 |
| Protein processing in endoplasmic reticulum | ATXN3L,UBE2D3,SEC63,RBX1,UBE2G1A,DNAJB1B,ATF4B1,CAPN2B,GANAB,RPN1 |
| Epstein-Barr virus infection | PSMD13,FCER2,IFNG,MAPK8,PSMD6,HDAC4,TYK2,HSPA2,NFKB2,LYN |
| Measles | cgr2b,SLAMF1,Fasl,HSPA2,TAB2,OAS1,PRKCQ,STAT3,DDX58,OAS1B |
| Influenza A | CCL5,AGFG1,STAT1,HSPA6,PIK3R5,MAPK10,HLA-DQA2,NFKBIB,PABPN1L,RAE1 |
| Herpes simplex infection | CLOCK,EEF1D,TRAF5,GTF2I,UBE2R2,IFNA14,BLB2,MHC2DAB,IFNA16,EP300 |
Protein Function
EIF2AK1 has several biochemical functions, for example, ATP binding,eukaryotic translation initiation factor 2alpha kinase activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK1 itself. We selected most functions EIF2AK1 had, and list some proteins which have the same functions with EIF2AK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | NOS2,CYP2K22,CYP26B1,CYP46A1.2,CYP2F2,FA2H,CYP4F11,CYP3A4,CYP2H1,SUOX |
| ATP binding | RHOBTB3,TESK1,DCLK1A,PRKCDA,MCM8,UBE2M,AK1,EIF4A1A,DHX32,UBA6 |
| eukaryotic translation initiation factor 2alpha kinase activity | EIF2AK2,ALPK2,EIF2AK3,EIF2AK4 |
| protein homodimerization activity | SLC24A6,SNX1,DST,NRF1,PITX2,FOXP3,ADH1,NR4A2,ACOT7,MAFA |
Interacting Protein
EIF2AK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK1.
HSP90AB1;nhaA;btuC;linkable pd173955 analogue;bosutinib;imatinib;CDC37
Resources
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References
- Cui, J; Han, SY; et al. c-Jun NH2-terminal kinase 2 alpha 2 promotes the tumorigenicity of human glioblastoma cells. CANCER RESEARCH 66:10024-10031(2006).
- Skalnikova, H; Vodicka, P; et al. Protein signaling pathways in differentiation of neural stem cells. PROTEOMICS 8:4547-4559(2008).
