EEF1E1
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Official Full Name
eukaryotic translation elongation factor 1 epsilon 1 -
Overview
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. -
Synonyms
EEF1E1;eukaryotic translation elongation factor 1 epsilon 1;P18;eukaryotic translation elongation factor 1 epsilon-1;AIMP3;aminoacyl tRNA synthetase complex interacting multifunctional protein 3;AIMP 3;Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3;ARS interacting multifunctional protein 3;Cyclin dependent kinase 6 inhibitor;Elongation factor p18;Homolog of rat elongation factor p18;MCA3_HUMAN;Multisynthase complex auxiliary component p18;Multisynthetase complex auxiliary component p18;p18 component of aminoacyl tRNA synthetase complex;p18 INK4c;p18 NK6;ARS-interacting multifunctional protein 3;p18 component of aminoacyl-tRNA synthetase complex
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
EEF1E1 involved in several pathways and played different roles in them. We selected most pathways EEF1E1 participated on our site, such as Cytosolic tRNA aminoacylation,Gene Expression,tRNA Aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EEF1E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| tRNA Aminoacylation | MADD,FARSB,AARS,DARS,FARS2,WARS2,AIMP2,EARS2,AIMP1,KARS |
| Gene Expression | TXNL4A,POLR3G,ZFP36L1B,SUZ12,ZNF92,ZNF560,TRDMT1,EIF2B1,ESR2B,ZNF649 |
| Cytosolic tRNA aminoacylation | MADD,AARS,FARSB,AIMP1,DARS,AIMP2,KARS |
Protein Function
EEF1E1 has several biochemical functions, for example, glutathione transferase activity,protein binding,translation elongation factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EEF1E1 itself. We selected most functions EEF1E1 had, and list some proteins which have the same functions with EEF1E1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF410,FAM117B,NPHP1,ELMO1,IRX1,INTS12,FOXP4,FHL1,KCNIP3,EXOC3 |
| translation elongation factor activity | EEF2A.2,EEF1A1,TSFM,EEF2A.1,TUFM,EEF1B2,EEF1DA,HBS1L,EEF2,EEF1D |
| glutathione transferase activity | GDAP1,GSTAL,GSTZ1,GRX2,GSTM3,GSTA3,GSTM7,GSTP2,MGST3,GSTT1B |
Interacting Protein
EEF1E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EEF1E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EEF1E1.
NAT9;gag;CALCOCO2;EIF1B;ARF6;Dlgap4;ssrna_ug
Resources
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References
- Kaiser, A; et al. Translational control of eIF5A in various diseases. AMINO ACIDS 42:679-684(2012).
- Park, JH; Dias, CAO; et al. Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes. PROTEIN ENGINEERING DESIGN & SELECTION 24:301-309(2011).
