EEF1D
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Official Full Name
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -
Overview
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19. -
Synonyms
EEF1D;eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein);elongation factor 1-delta;EF 1D;FLJ20897;Antigen NY CO 4;Antigen NY-CO-4;EEF 1D;EF 1 delta;EF-1-delta;EF1D;EF1D_HUMAN;Elongation factor 1 delta;Eukaryotic translation elongation factor 1 delta;Guanine nucleotide exchange protein;EF-1D;FP1047
Recombinant Proteins
- Mouse
- Rat
- Human
- Cynomolgus
- E.coli
- Mammalian Cell
- Wheat Germ
- Human
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His&T7
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
EEF1D involved in several pathways and played different roles in them. We selected most pathways EEF1D participated on our site, such as Eukaryotic Translation Elongation,Gene Expression,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with EEF1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Eukaryotic Translation Elongation | EEF1A1,EEF1A2,EEF1G,RPL35,EEF2,EEF1B2 |
| Herpes simplex infection | IRF9,FB06F03,C5,IKBKB,C3,IFNA13,CLOCKA,JAK2A,OAS2,Casp3 |
| Metabolism of proteins | TTR,DPAGT1,CTSG,PAPPA2,DOHH,VBP1,KDELR3,TIMM22,GPR116,CHCHD4 |
| Translation | APEH,EEF1A2,EEF1B2,EIF2B1,EEF1G,EIF5 |
| Gene Expression | TUBB3,RORAA,TRMT44,SCO1,HNRNPF,ZNF791,RXRBB,SETB,ZNF668,EFCAB11 |
| Translation Factors | EEF1G,EEF2B,EIF2B1,EEF1A2,EIF1,EEF1B2,EIF5A,PAIP1,EIF4EBP2 |
Protein Function
EEF1D has several biochemical functions, for example, DNA binding,activating transcription factor binding,heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EEF1D itself. We selected most functions EEF1D had, and list some proteins which have the same functions with EEF1D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| translation factor activity, RNA binding | CPEB2,EIF4H,SOX11,EIF2S2,EIF5,MTIF3,CPEB1,GTF2H2,ABCF1,EIF2S3 |
| activating transcription factor binding | HDAC1,DGKQ,MEF2C,MEF2D,HDAC7,GATA4,HDAC4,PRDM16,MEF2A,PSIP1 |
| protein binding | DNM1L,NELL1,MAPK8IP2,SLC6A4,IRF7,CEP164,C3orf62,BOK,DARS,LANCL2 |
| DNA binding | HES1,NPAS4,ZBTB17,BRD4,POLR2H,TOP2A,IRX1A,ABL1,ELF2B,ARNTL1B |
| translation elongation factor activity | TSFM,EEF2A.1,ABTB1,EEF1A1B,EEF2B,EEF1DB,EIF5A2,EEF1G,TUFM,EEF1A1L1 |
| signal transducer activity | HTR1AB,GHRHRL,IL10RA,GNGT2A,GNB5,PTGER1A,MTNR1AA,MRGPRB5,TAS2R129,TAAR10 |
| heat shock protein binding | HSPA8,SSUH2.2,GM5506,DNAJA3A,TFAM,PPP5C,DNAJA4,APAF1,FKBP5,SSUH2RS1 |
Interacting Protein
EEF1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EEF1D here. Most of them are supplied by our site. Hope this information will be useful for your research of EEF1D.
SIAH1;TPT1;EEF1G;ERP27;EEF1G;ATG7
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