EDA
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Official Full Name
ectodysplasin A -
Overview
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. -
Synonyms
EDA;ectodysplasin A;ectodermal dysplasia 1, anhidrotic , ED1, EDA2, ODT1, oligodontia 1;ectodysplasin-A;ED1 A1;ED1 A2;EDA1;HED;XHED;XLHED;oligodontia 1;ectodermal dysplasia protein;X-linked anhidroitic ectodermal dysplasia protein;ED1;EDA2;ODT1;ED1-A1;ED1-A2;STHAGX1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mus musculus
- Mammalian cells
- HEK293
- E.coli
- Human cells
- Mammalian Cell
- HEK293T
- E.coli expression system
- Non
- His
- Flag
- His&Flag&StrepII
- His&Fc&Avi
- Myc&DDK
- His&GST
Involved Pathway
EDA involved in several pathways and played different roles in them. We selected most pathways EDA participated on our site, such as Cytokine Signaling in Immune system,Cytokine-cytokine receptor interaction,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | CTSB,MKRN1,HUWE1,CTSE,ADAR,TRIM6,IFIT8,ERAP2,LILRB4,IFIT10 |
| TNFs bind their physiological receptors | EDAR,EDARADD |
| Cytokine Signaling in Immune system | SPRED3,FGF20A,PAQR3B,GBP2,PELI2,TNIP2,FGF18B,TRIM5,TRIM6,SPRED1 |
| TNFR2 non-canonical NF-kB pathway | EDAR,EDARADD |
| Cytokine-cytokine receptor interaction | CCL24,BMP7A,IL1B,CSF2RB,LTBR,TNFRSF21,IL24,TGFB2,IL11RA2,TNFSF8 |
Protein Function
EDA has several biochemical functions, for example, protein binding,receptor binding,tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDA itself. We selected most functions EDA had, and list some proteins which have the same functions with EDA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IGF2BP2,LRRFIP2,IFI35,UBA2,PSMA1,FAM133A,HMGB2,PCMT1,KLF17,NCK2 |
| tumor necrosis factor receptor binding | TRAF4,TRAF6,ERAP1,TNFSF11,TNFB,TNFSF15,TNFSF10L3,TRAF1,TNFSF4,TRAP1 |
| receptor binding | DVL3,TNFSF12,LRRC4B,RSPO3,NXPH1,LTA,CNPY3,NPPA,TNFSF13B,NXPH3 |
Interacting Protein
EDA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDA here. Most of them are supplied by our site. Hope this information will be useful for your research of EDA.
MAL;PLN;ATP6V0C;CYB561;EMP3;LEPROTL1;NIPAL3
EDA Related Signal Pathway
Resources
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References
- Prasanna, RR; Kamalanathan, AS; et al. Development of L-histidine immobilized CIM (R) monolithic disks for purification of immunoglobulin G. JOURNAL OF MOLECULAR RECOGNITION 28:129-141(2015).
- Kowalczyk-Quintas, C; Schuepbach-Mallepell, S; et al. Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:359-368(2015).
