ECSIT
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Official Full Name
ECSIT homolog -
Synonyms
ECSIT;ECSIT homolog (Drosophila);evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;signaling intermediate in Toll pathway evolutionarily conserved ortholog (mouse);SITPEC;likely ortholog of mouse signaling intermediate in
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ECSIT involved in several pathways and played different roles in them. We selected most pathways ECSIT participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ECSIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | RRAS2,CACNA2D2,AKT2,MAPK14B,TGFB1A,RASA2,RAC1,PDGFRA,CACNG7,MAP2K2 |
Protein Function
ECSIT has several biochemical functions, for example, oxidoreductase activity, acting on NAD(P)H,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ECSIT itself. We selected most functions ECSIT had, and list some proteins which have the same functions with ECSIT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on NAD(P)H | NDUFS8B,DECR1,NDUFS8A,DERL3,WDR93,MIOX,AIFM1 |
| protein binding | KLHDC5,IL1RL1,VAV3,PPM1A,SERPINI2,PLAU,SNX17,SFRP5,PPP1R13L,SMARCC2 |
Interacting Protein
ECSIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECSIT here. Most of them are supplied by our site. Hope this information will be useful for your research of ECSIT.
PSEN1;ACAD9;FARSA;APOE;PSEN2;SMURF1;A2M;DNAJB1
Resources
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References
- Chen, WN; Liu, LL; et al. Hepatitis B virus X protein increases the IL-1 beta-induced NF-kappa B activation via interaction with evolutionarily conserved signaling intermediate in Toll pathways (ECSIT). VIRUS RESEARCH 195:236-245(2015).
- Wi, SM; Park, J; et al. Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-kappa Bs in Toll-like receptor 4 signaling. MOLECULAR BIOLOGY OF THE CELL 26:151-160(2015).
