ECH1
-
Official Full Name
enoyl CoA hydratase 1, peroxisomal -
Overview
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. -
Synonyms
ECH1;enoyl CoA hydratase 1, peroxisomal;enoyl Coenzyme A hydratase 1, peroxisomal;delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial;HPXEL;dienoyl-CoA isomerase;peroxisomal enoyl-CoA hydratase 1;delta3,5-delta2,4-dienoyl-CoA isomerase
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ECH1 involved in several pathways and played different roles in them. We selected most pathways ECH1 participated on our site, such as Fatty Acid Biosynthesis,Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ECH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty Acid Biosynthesis | ACSL4A,ACSL1,MCAT,ACSBG2,ACSBG1,ACACA,ACSL1B,ECHDC2,ACSL4B,OLAH |
| Peroxisome | PEX11G,FAR2,CRAT,SCP2,PEX12,MPV17,ABCD4,ACSL1B,PEX19,ACSL3B |
Protein Function
ECH1 has several biochemical functions, for example, isomerase activity,protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ECH1 itself. We selected most functions ECH1 had, and list some proteins which have the same functions with ECH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| isomerase activity | PGAM1,TSTA3,HSD17B4,FKBP10B,GPR19,FKBP1AA,PPIAB,PBLD1,DSEL,PGAM1B |
| receptor binding | FGF8A,PTPRD,PIPOX,Fgf15,TMEM38A,HCST,NPFFL,CADM1A,FGF13B,Artn |
| protein binding | PTPRB,LRRC4B,ABT1,NAT2,STRADA,APOD,FAM20C,SHFM1,ADAMTS10,ALAS2 |
Interacting Protein
ECH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECH1.
TRAF1;FAM9B;EEF1G;STAT3;HTT;MCC;TIMP1;EEF1D;CSTF2;SERPINB9;PEX5;PAFAH1B3;purL
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