E2F3

  • Official Full Name

    E2F transcription factor 3

  • Overview

    This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

  • Synonyms

    E2F3;E2F transcription factor 3;E2F-3;transcription factor E2F3

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
E2F3-12247H Recombinant Human E2F3, His-tagged E.coli Human His 1-110a.a.
E2F3-118H Recombinant Human E2F3 Protein, His-tagged E.coli Human His
E2F3-27375TH Recombinant Human E2F3 Wheat Germ Human Non 133 amino acids
E2F3-3006H Recombinant Human E2F3 Protein, GST-tagged Wheat Germ Human GST
E2F3-4932M Recombinant Mouse E2F3 Protein Mammalian Cell Mouse His
E2F3-5118Z Recombinant Zebrafish E2F3 Mammalian Cell Zebrafish His
E2F3-6742HCL Recombinant Human E2F3 293 Cell Lysate HEK293 Human Non
E2F3-134HF Recombinant Full Length Human E2F3 Protein In Vitro Cell Free System Human Full L. 133 amino acids
E2F3-2596M Recombinant Mouse E2F3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
E2F3-2596M-B Recombinant Mouse E2F3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
E2F3-4112HF Recombinant Full Length Human E2F3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 133 amino acids

    Involved Pathway

    E2F3 involved in several pathways and played different roles in them. We selected most pathways E2F3 participated on our site, such as Assembly of the pre-replicative complex,Association of licensing factors with the pre-replicative complex,Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular Senescence HIST3H2BB,SUZ12B,CDKN2D,EED,CBX4,CBX8A,MINK1,RING1,RBB4L,UBN1
    Assembly of the pre-replicative complex E2F2,CDT1,E2F1,MCM8,GMNN
    CDC6 association with the ORC:origin complex MCM8,E2F2
    Association of licensing factors with the pre-replicative complex CDT1,GMNN,E2F1,E2F2
    Cell Cycle, Mitotic NCAPH2,BLZF1,CDKN2C,STIL,DCTN3,ENSAB,GMNN,SDCCAG8,CKS1B,CENPC1
    Bladder cancer TRP53,CDKN2A,MYC,MMP2,MAP2K2,DAPK3,VEGFA,SRC,CDH1,UPK3A
    Cell cycle BUB3,CSNK2B,MCM9,CDH1-A,POT1A,VRK1,CDC25A,CTDNEP1B,CDC45,OIP5

    Protein Function

    E2F3 has several biochemical functions, for example, core promoter binding,protein binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F3 itself. We selected most functions E2F3 had, and list some proteins which have the same functions with E2F3. You can find most of the proteins on our site.

    Function Related Protein
    core promoter binding E2F8,HDAC6,SAFB,INSM1A,ELK1,CALCOCO1,NPAS2,XBP1,NOTCH1,E2F1
    protein binding NIPSNAP3A,PAK2,EIF2B2,ZWINT,ADRB1,FGF3,LCP2,CBX1,RGS17,MID1
    transcription factor activity, sequence-specific DNA binding DMRTC1B,MYCL1,NEUROD1,HER5,SOX9,HOXA5,FOXB1B,NKX2-8,GLI4,NKX2-1

    Interacting Protein

    E2F3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F3 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F3.

    RB1;MSH2;HELLS;Sp1;E7;E7;MYBL2;MYO1C;SCD;TCERG1;SLC16A3;MYO1B;AKAP8

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