DUSP13
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Official Full Name
dual specificity phosphatase 13 -
Overview
Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation anddifferentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. -
Synonyms
DUSP13;dual specificity phosphatase 13;dual specificity protein phosphatase 13;BEDP;DUSP13A;DUSP13B;FLJ32450;TMDP;muscle-restricted DSP;branching-enzyme interacting DSP;dual specificity phosphatase SKRP4;testis- and skeletal-muscle-specific DSP
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
DUSP13 involved in several pathways and played different roles in them. We selected most pathways DUSP13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DUSP13 has several biochemical functions, for example, protein binding,protein tyrosine phosphatase activity,protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP13 itself. We selected most functions DUSP13 had, and list some proteins which have the same functions with DUSP13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine/serine/threonine phosphatase activity | DUSP8A,EPM2A,PTPMT1,PTPRQ,DUSP1,MTMR2,CDC14A,LRP8,DUSP2,DUSP5 |
| protein tyrosine phosphatase activity | EPM2A,PTP4A2A,DUSP22B,PTPRC,PTP4A1,PTPRM,MTMR6,DUSP26,DNAJC6,PTPN23 |
| protein binding | GTF2E1,TMED9,C12orf40,TRAPPC2L,VAV1,FBXL14,TPP1,GATC,SLC22A6,SDHA |
Interacting Protein
DUSP13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP13 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP13.
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