DTNBP1
-
Official Full Name
dystrobrevin binding protein 1 -
Overview
The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. -
Synonyms
DTNBP1;dystrobrevin binding protein 1;sdy;Bloc1s8;AW048963;dysbindin;5430437B18Rik;dysbindin;sandy;dysbindin-1;BLOC-1 subunit 8;HPS7 protein homolog;dystrobrevin-binding protein 1;hermansky-Pudlak syndrome 7 protein homolog;biogenesis of lysosome-related organelles complex 1 subunit 8
Recombinant Proteins
- Chicken
- Rat
- Human
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DTNBP1 involved in several pathways and played different roles in them. We selected most pathways DTNBP1 participated on our site, such as Clathrin derived vesicle budding,Golgi Associated Vesicle Biogenesis,Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with DTNBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vesicle-mediated transport | HIP1RB,COPG,RALAB,COPZ1,LOC479668,NAPB,BLOC1S6,HSPH1,GJA4,DNASE2 |
| Clathrin derived vesicle budding | CLVS2,CLVS1,HIP1RB,APPA,TPD52L1,YIPF6,CTSZ,TFR1B,PUM1,AP1B1 |
| Golgi Associated Vesicle Biogenesis | AP1B1,GAK,AP1G1,FTH1A,NAPAA,AP3S1,AP1S3A,AP4B1,TPD52,TBC1D8B |
| Membrane Trafficking | PLDN,TBC1D8B,SEC22A,SNX9,TGOLN2,SNX9A,YKT6,TERFA,ARCN1,SNF8 |
| trans-Golgi Network Vesicle Budding | CPD,DNASE2,TGOLN2,TPD52,HIP1RB,PICALMA,AP4B1,CLVS1,FTH1A,BLOC1S4 |
Protein Function
DTNBP1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DTNBP1 itself. We selected most functions DTNBP1 had, and list some proteins which have the same functions with DTNBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | POSTN,ABCB9,RPUSD4,UBE2V1,MCCC2,TPM3,HCK,CDKN1C,TXN,KRT6B |
Interacting Protein
DTNBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DTNBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DTNBP1.
SNAPIN;BLOC1S2;BLOC1S5;BLOC1S6;BLOC1S1
Resources
Related Services
Related Products
References
