DSC2
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Official Full Name
desmocollin 2 -
Overview
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. -
Synonyms
DSC2;desmocollin 2;DSC3;desmocollin-2;CDHF2;cadherin family member 2;desmosomal glycoprotein II;desmosomal glycoprotein III;desmosomal glycoprotein II/III;DG2;ARVD11;DGII/III;DKFZp686I11137
Recombinant Proteins
- Human
- Mouse
- Rat
- Bovine
- Schizosaccharomyces pombe
- Mus musculus
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cell
- Human Cell
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- Fc
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DSC2-478H | Recombinant Human DSC2 Protein, His-tagged | E.coli | Human | His | Arg136~Cys471 | |
| DSC2-2878H | Recombinant Human DSC2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DSC2-3856H | Recombinant Human DSC2 protein, His-tagged | HEK293 | Human | His | Met1-Arg684 |
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| DSC2-4832M | Recombinant Mouse DSC2 Protein | Mammalian Cell | Mouse | His |
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| Dsc2-8753R | Recombinant Rat Dsc2, His tagged | Human Cell | Rat | His | 1-694 a.a. |
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| DSC2-1159RCL | Recombinant Rat DSC2 cell lysate | Human Cell | Rat | Non |
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| DSC2-2051HCL | Recombinant Human DSC2 cell lysate | Human Cell | Human | Non |
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| DSC2-2352R | Recombinant Rat DSC2 protein(Met1-Pro694), hFc-tagged | HEK293 | Rat | Fc | Met1-Pro694 |
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| DSC2-2527H | Recombinant Human DSC2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| DSC2-2534M | Recombinant Mouse DSC2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DSC2-2534M-B | Recombinant Mouse DSC2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Dsc2-2662M | Recombinant Mouse Dsc2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| DSC2-2821H | Recombinant Human DSC2 protein(771-890 aa), C-His-tagged | E.coli | Human | His | 771-890 aa |
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| DSC2-4195HF | Recombinant Full Length Human DSC2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 847 amino acids |
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| DSC2-4443H | Recombinant Human DSC2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| RFL36737BF | Recombinant Full Length Bovine Desmocollin-2(Dsc2) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length of Mature Protein (90-863) |
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| RFL5242SF | Recombinant Full Length Schizosaccharomyces Pombe Uba Domain-Containing Protein 14(Ucp14) Protein, His-Tagged | E.coli expression system | Schizosaccharomyces pombe | His | Full L. Full Length (1-372) |
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| RFL5362MF | Recombinant Full Length Mouse Desmocollin-2(Dsc2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (136-902) |
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Involved Pathway
DSC2 involved in several pathways and played different roles in them. We selected most pathways DSC2 participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy,Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with DSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA5,ITGA10,ACTN4,ITGA7,ATP2A2,ACTG1,JUP,SLC8A1,TCF7L2,CACNG7 |
| Arrhythmogenic right ventricular cardiomyopathy | CTNNA2,DSP,DSG2,DES,CACNG3,CACNG2,JUP,CTNNA1,DAG1,CDH2 |
Protein Function
DSC2 has several biochemical functions, for example, calcium ion binding,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSC2 itself. We selected most functions DSC2 had, and list some proteins which have the same functions with DSC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | PKP2,DSP,CTNNA3,JUP,DSG2 |
| protein binding | FYB,CDT1,CLASP1,ZNF136,FCNA,PPP1R12A,MAPT,SMAD2,RNF146,CD28 |
| calcium ion binding | FSTL4,PVALB6,ANXA5B,PCDH1,GCA,ANXA3A,CCDC47,NOTCH1B,PCDH1G31,CALM4 |
Interacting Protein
DSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSC2.
DSG2;GABARAPL1
Resources
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References
- Saruta, H; Ishii, N; et al. Two Cases of Pemphigus Vegetans With IgG Anti-Desmocollin 3 Antibodies. JAMA DERMATOLOGY 149:1209-1213(2013).
- Arai, R; Okuda, H; et al. IgA pemphigus with non-pustular erythematous lesions and IgA antibodies to desmocollins 1 and 2. EUROPEAN JOURNAL OF DERMATOLOGY 23:362-365(2013).
