DPYSL2
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Official Full Name
dihydropyrimidinase-like 2 -
Overview
Collapsin Response Mediator Protein-2 (CRMP-2) is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity. CRMP-2 enhances axon elongation -
Synonyms
DPYSL2;dihydropyrimidinase-like 2;dihydropyrimidinase-related protein 2;CRMP2;DHPRP2;DRP 2;DRP2;unc-33-like phosphoprotein 2;collapsin response mediator protein hCRMP-2;N2A3;DRP-2;ULIP2;CRMP-2;ULIP-2
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- E.coli
- Wheat Germ
- Yeast
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
DPYSL2 involved in several pathways and played different roles in them. We selected most pathways DPYSL2 participated on our site, such as Axon guidance,BDNF signaling pathway,CRMPs in Sema3A signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPYSL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CRMPs in Sema3A signaling | DPYSL3,CDK5,DPYSL5A,NRP1A,CDK5R1B,SEMA3AA,DPYSL5B,SEMA3AB,DPYSL4,DPYSL2B |
| Regulation of Microtubule Cytoskeleton | CFL2,MAP1B,MARK2,TPPP,MARK1,TESK2 |
| Semaphorin interactions | PLXND1,DPYSL5B,SEMA4D,DPYSL5A,PLXNC1,DPYSL4,SEMA3AA,SEMA3A,DPYSL3,NRP1A |
| L1CAM interactions | SCN8A,EZRA,KIF4A,KCNQ2,CHL1,DCX,SCN2B,KIF4,NRP1A,CD24 |
| Developmental Biology | FGFR1B,KDR,PTPRA,DNM2,MYF6,COL4A3,ADAM23,CSNK2B,LEFTY1,CSNK2A2 |
| Axon guidance | KLB,FGF20A,COL6A2,PLXNB2,ARPC1A,SEMA4C,RAC2,DPYSL4,CNKSR1,CRMP1 |
| BDNF signaling pathway | GNB2L1,CDH2,DOK5,SYN1,LINGO1,CSNK2A1P,EIF4EBP1,EIF2S1,CDK5,MAP3K2 |
| Recycling pathway of L1 | DPYSL2B,NADL1.1,EZRA |
Protein Function
DPYSL2 has several biochemical functions, for example, dihydropyrimidinase activity,microtubule binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPYSL2 itself. We selected most functions DPYSL2 had, and list some proteins which have the same functions with DPYSL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | VPS41,MAPRE1A,KIF17,NUSAP1,ZNF207,TXNDC3,MAPT,KIF19,MTUS2,TRAF3IP1 |
| protein binding | DCC,PPP1R9B,LAIR2,GRIN1,ZNF238,UBE2W,MAPKAPK3,RAB5B,GSTZ1,SETBP1 |
| dihydropyrimidinase activity | DPYS |
| protein kinase binding | CCNL2,LAX1,CCNL1A,AKAP5,GHR,ATF2,MAP2K3,JAK2,TMEM173,ZFP36 |
Interacting Protein
DPYSL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPYSL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPYSL2.
DPYSL3;DPYSL3;DPYSL5;GORASP2;MICALL1;GRK1;DPYSL4
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References
- Tan, F; Wahdan-Alaswad, R; et al. Dihydropyrimidinase-like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma. CANCER SCIENCE 104:1586-1592(2013).
