DOK2

  • Official Full Name

    docking protein 2, 56kDa

  • Overview

    Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung.

  • Synonyms

    DOK2;docking protein 2, 56kDa;docking protein 2, 56kD;docking protein 2;Dok 2;p56dok 2;p56(dok-2);downstream of tyrosine kinase 2;p56DOK;p56dok-2

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DOK2-28083TH Recombinant Human DOK2, His-tagged E.coli Human His 21-133 a.a.
DOK2-2810H Recombinant Human DOK2 Protein, GST-tagged Wheat Germ Human GST
DOK2-4761M Recombinant Mouse DOK2 Protein Mammalian Cell Mouse His
DOK2-6847HCL Recombinant Human DOK2 293 Cell Lysate HEK293 Human Non
DOK2-1233H Recombinant Human DOK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
DOK2-2483M Recombinant Mouse DOK2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DOK2-2483M-B Recombinant Mouse DOK2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
Dok2-2630M Recombinant Mouse Dok2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
DOK2-3938HF Recombinant Full Length Human DOK2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 412 amino acids

    Involved Pathway

    DOK2 involved in several pathways and played different roles in them. We selected most pathways DOK2 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling,Cell surface interactions at the vascular wall,EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Angiopoietin receptor Tie2-mediated signaling GRB7,CDKN1A,AGTR1,CRK,BMX,GRB14,ELF1,ELF2
    Tie2 Signaling ANGPT2A,GRB14
    Hemostasis AKAP1B,CFD,CLEC1B,SRGN,HBBE3,HMG20B,FN1B,F11R.2,KIF5A,KIF15
    IL4-mediated signaling events MYB,IgG3,NIPAL1,TFF3,RETNLB,MYBL1,CCL26,IRF4,PARP14,EGR2
    EGFR1 Signaling Pathway APPL2,RBBP7,CEBPB,MAP3K2,REPS1,USP6NL,TNIP1,STXBP1A,ZPR1,EPS8
    IL-4 signaling Pathway ADRBK2,PAWR,IL4R.1,SPI1B,HMGA1-RS1
    Cell surface interactions at the vascular wall SLC7A10,FCER1GL,GRB14,SIRPA,CXADR,SLC7A6,GRB7,FN1B,PPIA,CD84
    IL2-mediated signaling events IKZF3,CISH,STAM2

    Protein Function

    DOK2 has several biochemical functions, for example, insulin receptor binding,protein binding,receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK2 itself. We selected most functions DOK2 had, and list some proteins which have the same functions with DOK2. You can find most of the proteins on our site.

    Function Related Protein
    insulin receptor binding PHIP,IGF1,FRS2A,IRS1,PTPN1,FRS3,PTPN11,DOK6,DOK7,INS
    transmembrane receptor protein tyrosine kinase adaptor activity BLNK,PIK3R1,IRS1,GAB2,SH2B2,TRAT1,STAP1,FRS2,SHC1
    protein binding TNIP1,ASTE1,FRMD5,KRT17,PSMD2,PGF,FCRL2,DNAJB2,SDHA,DRD3
    receptor signaling protein activity TYROBP,ARAF,ARF1,IFITM1,RAF1A,DCLK1,DOK4,RGS14A,Siglece,PLCG1

    Interacting Protein

    DOK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK2.

    POT1;LCK;STAT3;CRK;CRK;CRKL;DOK3;APPL1;CFLAR;SPOP;SSSCA1

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