DNMT3A

What is Dnmt3a protein?

Dnmt3a protein, also known as DNA (cytosine-5)-methyltransferase 3A, is an enzyme that plays a crucial role in DNA methylation. It is involved in the addition of a methyl group to the 5th carbon of cytosine residues in DNA, leading to the formation of 5-methylcytosine. DNA methylation is an epigenetic modification that regulates gene expression and is essential for normal development and cellular function.

What is the function of Dnmt3a protein?

Dnmt3a primarily functions during early embryonic development and is responsible for establishing the DNA methylation patterns in the genome. It is also involved in maintaining DNA methylation patterns throughout life by ensuring faithful replication and inheritance of methylation marks during cell division.

Dnmt3a mutations have been implicated in several diseases, including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), where abnormal DNA methylation patterns contribute to the development of these malignancies.

Dnmt3a related signaling pathway

Dnmt3a plays a crucial role in epigenetic regulation by controlling gene expression through DNA methylation. Dysregulation of Dnmt3a has been associated with various diseases, including cancer. In particular, mutations in Dnmt3a have been identified in acute myeloid leukemia (AML) patients.

The exact signaling pathway involving Dnmt3a is still being investigated. However, it is known that Dnmt3a interacts with other proteins and factors involved in DNA methylation, chromatin remodeling, and gene expression regulation. These include Dnmt3L (Dnmt3a cofactor), histone modifying enzymes, transcription factors, and chromatin remodeling complexes.

Dnmt3a Related Diseases

•  Acute Myeloid Leukemia (AML): Dnmt3a mutations are frequently found in patients with AML, particularly in cases with normal cytogenetics. These mutations contribute to abnormal DNA methylation patterns and impaired differentiation of hematopoietic stem cells.
•  Myelodysplastic Syndromes (MDS): Dnmt3a mutations are also observed in patients with MDS, a heterogeneous group of bone marrow disorders characterized by ineffective blood cell production. Dnmt3a mutations are associated with dysregulated DNA methylation and altered hematopoietic stem cell function.
•  Solid Tumors: Dnmt3a mutations have been reported in various solid tumors, although their prevalence in these cancers is relatively low compared to hematological malignancies.
•  Cancer research and therapy: Dnmt3a mutations are frequently found in various cancers, including acute myeloid leukemia (AML). Understanding the role of Dnmt3a mutations in cancer development and progression can help in the development of targeted therapies. Inhibitors targeting Dnmt3a activity are also being investigated as potential cancer treatments.
•  Biomarker discovery: Dnmt3a mutations or altered expression levels have been identified as potential biomarkers for several diseases, including cancer. Detection of these biomarkers can assist in disease diagnosis, prognosis, and monitoring treatment response.

Biomedical Application of Dnmt3a Protein

•  Cancer research and therapy: Dnmt3a mutations are frequently found in various cancers, including acute myeloid leukemia (AML). Understanding the role of Dnmt3a mutations in cancer development and progression can help in the development of targeted therapies. Inhibitors targeting Dnmt3a activity are also being investigated as potential cancer treatments.
•  Epigenetic research: Studying the function and regulation of Dnmt3a contributes to understanding epigenetic modifications and their impact on gene expression and cellular processes. This knowledge can aid in deciphering the mechanisms underlying various diseases and developing new therapeutic strategies.
•  Reprogramming of stem cells: Dnmt3a plays a crucial role in the establishment and maintenance of DNA methylation patterns during embryonic development. Manipulating Dnmt3a expression or activity can influence the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), allowing for the generation of patient-specific stem cells for disease modeling and regenerative medicine.

•  Reprogramming of stem cells: Dnmt3a plays a crucial role in the establishment and maintenance of DNA methylation patterns during embryonic development. Manipulating Dnmt3a expression or activity can influence the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), allowing for the generation of patient-specific stem cells for disease modeling and regenerative medicine.

DNMT3A has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity,DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT3A itself. We selected most functions DNMT3A had, and list some proteins which have the same functions with DNMT3A. You can find most of the proteins on our site.

DNMT3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT3A here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT3A.

EZH2;H3F3A;SETDB1