DMRT1
-
Official Full Name
doublesex and mab-3 related transcription factor 1 -
Overview
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like;DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining;pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific;and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene;is hemizygous. -
Synonyms
DMRT1;doublesex and mab-3 related transcription factor 1;doublesex- and mab-3-related transcription factor 1;DM domain expressed in testis 1;DMT1;DM domain expressed in testis protein 1
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DMRT1-11663Z | Recombinant Zebrafish DMRT1 | Mammalian Cell | Zebrafish | His |
|
|
| DMRT1-11775Z | Recombinant Zebrafish DMRT1 | Mammalian Cell | Zebrafish | His |
|
|
| DMRT1-27093TH | Recombinant Human DMRT1 | Wheat Germ | Human | Non | 373 amino acids |
|
| DMRT1-2709H | Recombinant Human DMRT1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| DMRT1-3742C | Recombinant Chicken DMRT1 | Mammalian Cell | Chicken | His |
|
|
| DMRT1-4649M | Recombinant Mouse DMRT1 Protein | Mammalian Cell | Mouse | His |
|
|
| DMRT1-6898HCL | Recombinant Human DMRT1 293 Cell Lysate | HEK293 | Human | Non |
|
|
| DMRT1-128HF | Recombinant Full Length Human DMRT1 Protein | In Vitro Cell Free System | Human | Full L. 373 amino acids |
|
|
| DMRT1-2414M | Recombinant Mouse DMRT1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| DMRT1-2414M-B | Recombinant Mouse DMRT1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| Dmrt1-2587M | Recombinant Mouse Dmrt1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| DMRT1-4029HF | Recombinant Full Length Human DMRT1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 373 amino acids |
|
| DMRT1-6242H | Recombinant Human DMRT1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
Involved Pathway
DMRT1 involved in several pathways and played different roles in them. We selected most pathways DMRT1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DMRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DMRT1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin binding,core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DMRT1 itself. We selected most functions DMRT1 had, and list some proteins which have the same functions with DMRT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ELF2A,ZNF354B,ZFP367,HNF1A,HOXC4A,NFIL3,SLC30A9,PHF1,ELF1,FOXP3A |
| protein homodimerization activity | FLT3LG,PGCP,NACC2,MYOM1,HSD17B4,CBLN1,PTPRO,MAP3K12,SMAD2,GSTM3 |
| protein heterodimerization activity | STX1A,FLOT2,CRLF1,OSTA,HIST2H2AA4,H2-AB1,HIST3H2BB,MYOD1,VAPB,BMP2 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | CEBPA,SOX17,MYOCD,ALX1,DLX2,MYF5,IRF2,BARHL1A,CSRNP2,MYOD1 |
| chromatin binding | YBX2,TSHZ3,SATB1,TP63,GPR30,PRDM11,TCF7L1A,UBTFL,KAT2B,TICRR |
| RNA polymerase II regulatory region sequence-specific DNA binding | ETV3,RELA,GATA1A,ZBTB12.2,PKNOX2,PRKCBP1L,FOXF1,ZNF584,JARID2,FOXK1 |
| core promoter proximal region sequence-specific DNA binding | DMRTC1C2,DMRTC1B,DMRTA1,GATA3,ZFP516,DMRT2A,SMAD3,DMRT2,DMRT2B,CXXC1 |
| metal ion binding | DNLZ,TNKS2,ALKBH7,ATP11A,CHPT1,NR5A1B,ZFP750,CIT,FYN,RORAB |
Interacting Protein
DMRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMRT1.
Dlg4
Resources
Related Services
Related Products
References
- Li, XY; Li, Z; et al. Expression characterization of testicular DMRT1 in both Sertoli cells and spermatogenic cells of polyploid gibel carp. GENE 548:119-125(2014).
- Liu, MX; Hu, ZB; et al. Scanning of novel cancer/testis proteins by human testis proteomic analysis. PROTEOMICS 13:1200-1210(2013).
