DMAP1
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Official Full Name
DNA methyltransferase 1 associated protein 1 -
Overview
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] -
Synonyms
DMAP1;DNA methyltransferase 1 associated protein 1;EAF2;SWC4;MEAF2;DNMAP1;DNMTAP1;DNA methyltransferase 1-associated protein 1;DNMT1 associated protein 1;DNMT1-associated protein 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DMAP1-10594Z | Recombinant Zebrafish DMAP1 | Mammalian Cell | Zebrafish | His |
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| DMAP1-2699H | Recombinant Human DMAP1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DMAP1-6901HCL | Recombinant Human DMAP1 293 Cell Lysate | HEK293 | Human | Non |
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| DMAP1-6902HCL | Recombinant Human DMAP1 293 Cell Lysate | HEK293 | Human | Non |
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| Dmap1-2582M | Recombinant Mouse Dmap1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
DMAP1 involved in several pathways and played different roles in them. We selected most pathways DMAP1 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | JHDM1D,ATXN7L3,PHF21A,ENY2,KDM4C,JMJD6,KDM3B,KDM5A,EP400,MSL1 |
| HATs acetylate histones | KAT6A,ATXN7,ELP3,KANSL2,ING3,ELP2,SAP130,KAT7A,MSL1,MSL3 |
| Chromatin modifying enzymes | BRD1,KDM5A,SAP30,KDM6AL,BRPF1,SMYD2,ELP3,ZZZ3,ELP4,NCOA2 |
Protein Function
DMAP1 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DMAP1 itself. We selected most functions DMAP1 had, and list some proteins which have the same functions with DMAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | EID1,NEUROD2,SNW1,AEBP1,MNT,E2F8,RELB,CBFA2T2,NCOR2,SKOR1 |
| RNA polymerase II repressing transcription factor binding | GATA6,TBP,MTA2,GTF2A2,BBS1,STAT3,TCF7L2,BBS5,BBS4,TCERG1 |
| protein binding | C6orf108,RTN4RL1B,ARHGAP26,INPPL1,CKB,ZNRF1,RANBP3,CRLF1,NOTCH1,HYAL2 |
Interacting Protein
DMAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMAP1.
MRGBP;ACTL6A;ZNHIT1;TSG101;HSPB1;YEATS4;DBP;Ruvbl1;Jup;HTZ1
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References
- Uzdensky, A; Demyanenko, S; et al. Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin. TUMOR BIOLOGY 35:8225-8233(2014).
- Lewandowska, M; Furtak, J; et al. An Analysis of the Prognostic Value of IDH1 (Isocitrate Dehydrogenase 1) Mutation in Polish Glioma Patients. MOLECULAR DIAGNOSIS & THERAPY 18:45-53(2014).
