DIO2
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Official Full Name
deiodinase, iodothyronine, type II -
Overview
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3,5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
DIO2;deiodinase, iodothyronine, type II;type II iodothyronine deiodinase;type 2 DI;type-II 5 deiodinase;type-II 5-deiodinase;iodothyronine type II deiodinase;5DII;DIOII;AI324267
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- Fundulus heteroclitus (Killifish) (Mummichog)
- Bovine
- Sus scrofa (Pig)
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Yeast
- E.coli expression system
- GST
- His
- His&MBP
- His&GST
- His&Fc&Avi
Involved Pathway
DIO2 involved in several pathways and played different roles in them. We selected most pathways DIO2 participated on our site, such as Amine-derived hormones,Metabolism,Metabolism of amino acids and derivatives, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | SLC25A1A,LOC100686744,CYP2W1,GYG1B,SLC4A1B,NUDT4A,ETFB,NUDT11,GLS2B,OMD |
| Amine-derived hormones | TPH2,CGA,DDC,DBH |
| Selenium Pathway | TXNRD3IT1,MSRB1,CRP,PRDX3,SAA2,SEP15,PRDX2,SAA4,SELK,SELT |
| Metabolism of amino acids and derivatives | PCBD1,SLC25A2,HIBADH,SLC6A7,NAALAD2,CKB,TPH2,HIBADHA,UROC1,OAZ1 |
| Selenium Metabolism and Selenoproteins | SP3,CREM,TXNRD3IT1,FBXO17,SELT,SELENBP1,TRNAU1AP,TXNRD2,SELK,MSRB1 |
| Thyroid hormone signaling pathway | RCAN2,PLCE1,BMP4,MED13,ATP1A3,PIK3R2,PIK3CD,PLCD4,FOXO1,DIO1 |
Protein Function
DIO2 has several biochemical functions, for example, selenium binding,thyroxine 5-deiodinase activity,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DIO2 itself. We selected most functions DIO2 had, and list some proteins which have the same functions with DIO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| selenium binding | SELT,GPX3,GPX1,SELENBP2,RPH3A,DIO1,SEP15,SEPP1,SELENBP1 |
| ubiquitin protein ligase binding | YWHAZ,UQCRC1,TOLLIP,ERBB2,UBE2O,CDC34,USP25,POLR2A,SUMO2,SMAD6 |
| thyroxine 5-deiodinase activity | DIO3,DIO3B,DIO1,DIO3A |
Interacting Protein
DIO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIO2.
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References
- Matsumoto, C; Ito, M; et al. Genes that characterize T-3-predominant Graves' thyroid tissues. EUROPEAN JOURNAL OF ENDOCRINOLOGY 168:137-144(2013).
- Nassar, M; Halle, I; et al. Detection of long-term influence of prenatal temperature stimulation on hypothalamic type-II iodothyronine deiodinase in juvenile female broiler chickens using a novel immunohistochemical amplification protocol. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 179:120-124(2015).
