DHX8

  • Official Full Name

    DEAH (Asp-Glu-Ala-His) box polypeptide 8

  • Overview

    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

  • Synonyms

    DHX8;DEAH (Asp-Glu-Ala-His) box polypeptide 8;DDX8, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8 (RNA helicase);ATP-dependent RNA helicase DHX8;HRH1;PRP22;PRPF22;ATP dependent RNA helicase DHX8;DDX 8;DDX8;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8 (RNA helicase);DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8;DEAD/H box polypeptide 8;DEAH (Asp Glu Ala His) box polypeptide 8;DEAH box polypeptide 8;DEAH box protein 8;DHX 8;DHX8_HUMAN;HRH 1;PRP 22;PRPF 22;RNA helicase HRH 1;RNA helicase HRH1;DEAH-box protein 8;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)

Recombinant Proteins

  • Human
  • Mouse
  • Wheat Germ
  • E.Coli or Yeast
  • Mammalian Cell
  • HEK293
  • HEK293T
  • GST
  • Non
  • His
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
DHX8-2615H Recombinant Human DHX8 Protein, GST-tagged Wheat Germ Human GST
DHX8-27450TH Recombinant Human DHX8 Wheat Germ Human Non 100 amino acids
Dhx8-3752M Recombinant Mouse Dhx8, His-tagged E.Coli or Yeast Mouse His 1244
DHX8-4585M Recombinant Mouse DHX8 Protein Mammalian Cell Mouse His
DHX8-2371M Recombinant Mouse DHX8 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DHX8-2371M-B Recombinant Mouse DHX8 Protein Pre-coupled Magnetic Beads HEK293 Mouse
Dhx8-2562M Recombinant Mouse Dhx8 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
DHX8-2605H Recombinant Human DHX8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    DHX8 involved in several pathways and played different roles in them. We selected most pathways DHX8 participated on our site, such as Spliceosome,mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA processing SF3A3,NONO,SREK1,WBP4,ZFP346,LSMD1,PTBP2,RBM4B,DDX20,LOC100862398
    Spliceosome PQBP1,SNRPE,CTNNBL1,SR140,RP9,ISY1,DDX42,ALYREF,SRSF3,U2AF2B

    Protein Function

    DHX8 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX8 itself. We selected most functions DHX8 had, and list some proteins which have the same functions with DHX8. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding RIPK3,FZD1,DNM1L,SYNE1,P2RX2,TRA@,SORD,SLC22A1,CTSC,PTPRM
    protein binding TAF1B,DNPEP,BATF2,TCOF1,KIAA1958,TRPC6,RNF111,ASCL1,RPL4,SLIT2
    ATP binding DNA2,FIGNL1,ACSM2,ACTC1B,GLUD1,PAK2A,IPMK,BCS1L,RPS6KAL,BMPR1BA
    poly(A) RNA binding CSTF2T,ADD1,CRNKL1,HNRNPH3,RPL26,GM5506,PPIG,AGO3,UBFD1,XPO5
    ATP-dependent RNA helicase activity FAM120B,DDX46,DDX39,EIF4A1A,DDX41,DDX18,DDX49,DDX3X,DDX23,DHX36

    Interacting Protein

    DHX8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX8 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX8.

    CHERP;NKAP;ISY1;SRPK2;SRPK1;USP12;SMAD3;SMAD2;PRPF40A;MFAP1;PRPF38A;ZCCHC10;THOC1;SAP30BP;RBMX2

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