DHRS4
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Official Full Name
dehydrogenase/reductase (SDR family) member 4 -
Overview
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones. -
Synonyms
DHRS4;dehydrogenase/reductase (SDR family) member 4;dehydrogenase/reductase SDR family member 4;FLJ11008;humNRDR;SCAD SRL;SDR SRL;SDR25C2;short chain dehydrogenase/reductase family 25C;member 2;mouNRDR;NDRD;RRD;AI043103;AI790593;Carbonyl reductase;CR;D14Ucla2;DHRS4_HUMAN;NADPH dependent carbonyl reductase/NADP retinol dehydrogenase;NADPH dependent retinol dehydrogenase/reductase;NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase;NADPH-dependent retinol dehydrogenase/reductase;NRDR;Peroxisomal short chain alcohol dehydrogenase;Peroxisomal short-chain alcohol dehydrogenase;PHCR;PRO1800;PSCD;SCAD-SRL;SCADSRL;Short chain dehydrogenase/reductase family member 4;Short-chain dehydrogenase/reductase family member 4;UNQ851;NADP-dependent retinol dehydrogenase;dehydrogenase/reductase (SDR family) member 4 like 2A;short chain dehydrogenase/reductase family 25C, member 1;short chain dehydrogenase/reductase family 25C, member 2;SDR-SRL;SDR25C1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
DHRS4 involved in several pathways and played different roles in them. We selected most pathways DHRS4 participated on our site, such as Metabolic pathways,Peroxisome,RA biosynthesis pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHRS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| retinol biosynthesis | CES5A,RBP5,DHRS9 |
| Metabolic pathways | NDUFS8A,CYP3A65,CHPF,GMPS,PGM1,PAPSS1,MCEE,BCAT1,PI4KAA,PNLIP |
| Retinol metabolism | RDH10A,UGT1A7,DHRS9,CYP2C54,UGT2A1,CYP2C45,UGT2A2,CYP2C39,ADH2-1,CYP2C18 |
| RA biosynthesis pathway | SDR16C5,AKR1C6,CYP26A1,DHRS9,CRABP1B,ADH8A,ALDH8A1,CRABP1,RDH10,RDH14A |
| Signal Transduction | PRICKLE1B,RGS12,ARHGEF1A,BCL9L,FSTL1A,CRHR2,ANXA1B,DNER,SKILB,GRB10A |
| Peroxisome | DAO.3,CAT,HMGCL,GSTK1,SLC27A2,PXMP4,IDH2,HACL1,ANI_1_2390104,NUDT12 |
| the visual cycle I (vertebrates) | RBP3,RBP5 |
| Signaling by Retinoic Acid | DHRS3,CRABP1,RARG,RDH14A,PDK3,RDH13,RARGA,FABP11A,PDK4,RDH10 |
Protein Function
DHRS4 has several biochemical functions, for example, 3-keto sterol reductase activity,alcohol dehydrogenase [NAD(P)+] activity,carbonyl reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHRS4 itself. We selected most functions DHRS4 had, and list some proteins which have the same functions with DHRS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-keto sterol reductase activity | HSD17B7,CBR3 |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | DCXR,AKR1C4,AKR1C2,CBR1,AKR1C21,AKR1C3,AKR1C6,NDUFS7 |
| receptor binding | F7,CAPRIN2,NUDT7,ADM,RSPO1,TRIM24,FGF12A,IDUA,PDGFRB,LYN |
| carbonyl reductase (NADPH) activity | CBR3,DHRS2,CBR2,CBR1 |
Interacting Protein
DHRS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHRS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHRS4.
PEX14;PEX5
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