DGKZ
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Official Full Name
diacylglycerol kinase, zeta -
Overview
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. -
Synonyms
DGKZ;diacylglycerol kinase, zeta;diacylglycerol kinase, zeta 104kDa;diacylglycerol kinase zeta;DAGK5;DAGK6;DGK ZETA;hDGKzeta;DAG kinase zeta;diglyceride kinase zeta;DGK-ZETA
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Insect Cell
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- His&T7
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
DGKZ involved in several pathways and played different roles in them. We selected most pathways DGKZ participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | IPMK,TMEM55B,PLCD3,INPP5E,PIK3R2,OCRL,PLCG1,PIK3C2B,PPIP5K2,PIK3R3A |
| Glycerolipid metabolism | GK,MOGAT3,DGAT1,AGPAT4,AGPAT1,MOGAT2,AKR1B1,DGAT1A,Cel,LIPCA |
| Choline metabolism in cancer | RPS6KB2,PDGFB,PDGFA,PDGFRA,SLC5A7,PIP5K1A,EGF,WAS,MTOR,HIF1A |
| Glycerophospholipid metabolism | DGKA,PLA2G4A,PPAP2D,PLA2G4F,PLA2G4D,LPCAT1,GPD2,PLB1,AGPAT6,CDIPT |
| Phospholipase D signaling pathway | RRAS2,PLCB3,TSC2,RRAS,PDGFD,PIK3R1,GRM8,INS2,PIK3CG,Adcy4 |
| Metabolic pathways | HPRT1,PDHX,EBP,GAMT,LPIN3,LTA4H,GALNTL4,ATP6V0B,HIBCH,DHRS9 |
Protein Function
DGKZ has several biochemical functions, for example, ATP binding,diacylglycerol kinase activity,enzyme inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKZ itself. We selected most functions DGKZ had, and list some proteins which have the same functions with DGKZ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid kinase activity | PIK3C2B,TAE1 |
| protein binding | VAMP8,RAB33B,SLMAP,PSMD7,CHMP6,C5orf13,CCDC101,PMP22,KCTD13,CST9L |
| enzyme inhibitor activity | ATPIF1,ATPIF1B,ANGPTL3,OAZ2A,APBA3,FRY,UGT1A1,PDE6H,HSPBP1,ARRB1 |
| metal ion binding | Acsm2a,SALL1,ZDHHC13,RHOU,TET3,AMPD3,PDLIM3B,PC,COQ7,RPS27.2 |
| diacylglycerol kinase activity | DGKD,TAE1,DGKA,AGK,DGKQ,DGKG,DGKAA,DGKB,DGKE |
| protein C-terminus binding | JAK2,TRP53,ZBTB16,XRCC4,PDZD3,BCL10,CEP120,ERCC4,VAMP2,HOMER3 |
| ATP binding | ATP7A,UCK2A,RFC4,CLCN4-2,ACTG1,ATAD1A,STK17B,GLULB,MTHFS,PIK3C2B |
Interacting Protein
DGKZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKZ here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKZ.
SAT1;MAPK6;GRINL1A;q8ckj5_yerpe;tnp_8;npm_alk;ARRB2;ARRB1;CBX8
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References
- Wang, LCS; Lo, A; et al. Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity. CANCER IMMUNOLOGY RESEARCH 2:154-166(2014).
- Wheeler, ML; Dong, MB; et al. Diacylglycerol Kinase zeta Limits B Cell Antigen Receptor-Dependent Activation of ERK Signaling to Inhibit Early Antibody Responses. SCIENCE SIGNALING 6:-(2013).
