DERL3
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Official Full Name
Der1-like domain family, member 3 -
Overview
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
DERL3;Der1-like domain family, member 3;C22orf14, chromosome 22 open reading frame 14;derlin-3;derlin 3;FLJ43842;IZP6;MGC71803;C22orf14;Degradation in endoplasmic reticulum protein 3;DER 3;Der1 like domain family member 3;Der1 like protein 3;Der1-like protein 3;DER3;DERL 3;DERL3_HUMAN;Derlin 3 protein;Derlin3;DERtrin 3;DERtrin-3;DERtrin3;IZP 6;LLN 2;LLN2
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Mus musculus
- Bovine
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DERL3-11146Z | Recombinant Zebrafish DERL3 | Mammalian Cell | Zebrafish | His |
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| DERL3-2548H | Recombinant Human DERL3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DERL3-4652C | Recombinant Chicken DERL3 | Mammalian Cell | Chicken | His |
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| DERL3-224HCL | Recombinant Human DERL3 lysate | HEK293 | Human | Non |
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| DERL3-2475HF | Recombinant Full Length Human DERL3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 205 amino acids |
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| RFL25269MF | Recombinant Full Length Mouse Derlin-3(Derl3) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-228) |
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| RFL25602BF | Recombinant Full Length Bovine Derlin-3(Derl3) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length (1-231) |
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| RFL7736HF | Recombinant Full Length Human Derlin-3(Derl3) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-235) |
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Involved Pathway
DERL3 involved in several pathways and played different roles in them. We selected most pathways DERL3 participated on our site, such as Apoptosis,Apoptosis Modulation by HSP70,Ceramide signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DERL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ceramide signaling pathway | CRADD,CTSD,PAWR,EGF |
| Apoptosis Modulation by HSP70 | CASP2 |
| Apoptosis | PIK3R2,HDR,HIST1H1D,CDK5RAP2,PLECA,DAPK1,STK24A,DSG3,STK26,RELA |
Protein Function
DERL3 has several biochemical functions, for example, DNA binding,FAD binding,NAD(P)H oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DERL3 itself. We selected most functions DERL3 had, and list some proteins which have the same functions with DERL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TTC39B,CAPG,FIBPB,FTCD,PAAF1,SYK,TPRKB,ARHGDIA,HEXIM1,ZNF155 |
| DNA binding | ZNF507,TP53,FLI1B,BACH1A,ZNF354B,SP110,RPS3,HIST1H2AK,ZBTB18,ZNF350 |
| oxidoreductase activity, acting on NAD(P)H | AIFM1,MIOX,NDUFS8B,DECR1,NDUFS8A,WDR93,ECSIT |
| electron carrier activity | COX11,GCDHA,ACADSB,GLRX5,AKR7A2,ACAD8,NDUFS6,CYP1A2,AOX4,AKR7A3 |
| protein dimerization activity | TWIST1B,ZBED6,BETA3,DAO1,FBXW11A,HER4.2,AIFM1,USF1L,ASCL5,NHLH2 |
| NAD(P)H oxidase activity | NOX4,AIFM1,KMO,DUOX2,CYB5R4 |
| FAD binding | COQ6,DAO1,CYB5R3,DAO.3,DAO.2,MICAL2,DAO,DAO.1,AIFM1,CRY2 |
Interacting Protein
DERL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DERL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DERL3.
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