DERL1

  • Official Full Name

    Der1-like domain family, member 1

  • Overview

    Derlin-1 also known as degradation in endoplasmic reticulum protein 1 is a protein that in humans is encoded by the DERL1 gene . It is a member of the rhomboid-like clan of polytopic membrane proteins.

  • Synonyms

    DERL1;Der1-like domain family, member 1;derlin-1;DER 1;DER1;derlin 1;FLJ13784;MGC3067;PRO2577;DERtrin-1;der1-like protein 1;degradation in endoplasmic reticulum protein 1;DER-1;FLJ42092

Recombinant Proteins

  • Rhesus macaque
  • Zebrafish
  • Chicken
  • Human
  • Mouse
  • Bovine
  • Dictyostelium Discoideum
  • Mus musculus
  • Pongo Abelii
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • E.coli expression system
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DERL1-1244R Recombinant Rhesus monkey DERL1 Protein, His-tagged Mammalian Cell Rhesus macaque His
DERL1-12615Z Recombinant Zebrafish DERL1 Mammalian Cell Zebrafish His
DERL1-1494C Recombinant Chicken DERL1 Mammalian Cell Chicken His
DERL1-2546H Recombinant Human DERL1 Protein, GST-tagged Wheat Germ Human GST
DERL1-4523M Recombinant Mouse DERL1 Protein Mammalian Cell Mouse His
DERL1-6971HCL Recombinant Human DERL1 293 Cell Lysate HEK293 Human Non
DERL1-1069R Recombinant Rhesus Macaque DERL1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
DERL1-1069R-B Recombinant Rhesus Macaque DERL1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DERL1-2336M Recombinant Mouse DERL1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DERL1-2336M-B Recombinant Mouse DERL1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
DERL1-2474HF Recombinant Full Length Human DERL1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 251 amino acids
RFL11619BF Recombinant Full Length Bovine Derlin-1(Derl1) Protein, His-Tagged E.coli expression system Bovine His Full L. Full Length (1-251)
RFL22195DF Recombinant Full Length Dictyostelium Discoideum Probable Derlin-1 Homolog(Derl1) Protein, His-Tagged E.coli expression system Dictyostelium Discoideum His Full L. Full Length (1-242)
RFL28598HF Recombinant Full Length Human Derlin-1(Derl1) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-251)
RFL7836MF Recombinant Full Length Mouse Derlin-1(Derl1) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-251)
RFL9795PF Recombinant Full Length Pongo Abelii Derlin-1(Derl1) Protein, His-Tagged E.coli expression system Pongo Abelii His Full L. Full Length (1-251)

    Involved Pathway

    DERL1 involved in several pathways and played different roles in them. We selected most pathways DERL1 participated on our site, such as Protein processing in endoplasmic reticulum,Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with DERL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum MBTPS2,TXNDC5,FBXO6,UGGT2,LMAN2,HERPUD1,HYOU1,CANX,DNAJC5B,HSPA5
    Amyotrophic lateral sclerosis (ALS) BCL2L1,MAP3K5,DAXX,CYCS,NEFL,TNF,GRIN1,BAD,TOMM40,MAP2K6

    Protein Function

    DERL1 has several biochemical functions, for example, ATPase binding,MHC class I protein binding,protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DERL1 itself. We selected most functions DERL1 had, and list some proteins which have the same functions with DERL1. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin-specific protease binding SART3,RAD23A,SELS,MARCH6,PARK7,AMFR,VCP,PARK2,VPS24,CHMP3
    ubiquitin protein ligase binding UBE2KB,MAGEA2,SMAD3,NGFR,PRKACA,RB1,PIAS1,SMAD7,PACRG,UBE2N
    protease binding CST3,VWF,ADAMTS4,COMP,ITGAV,CAST,BCL2,TP53,OS9,ALPI
    MHC class I protein binding HLA-E,LILRB1,TAPBP,CD244,CD8A,TUBB4B,ATP5A1,LILRB2,ATP5B,Pilrb1
    receptor activity Pla2r1,MED16,GFRA4A,CUBN,Tnfrsf22,ABP1,GFRA1B,LILRA3,CADM4,THRAP3
    ATPase binding PEX19,DNAJC10,SNTA1,ATPIF1B,SYVN1,NR1H2,ATP1B1,ATPIF1,RAB4A,ATP1B2
    protein binding RNF139,CCKBR,RASD1,PPIG,BAAT,JAK1,IMP4,RORB,CUBN,LGR5

    Interacting Protein

    DERL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DERL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DERL1.

    TCF25;HM13;CFTR;BCAP31;VIMP;XBP1;ALB;US11;VCP

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