DEFA1
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Official Full Name
defensin, alpha 1 -
Overview
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. -
Synonyms
DEFA1;defensin, alpha 1;DEF1, DEFA2, defensin, alpha 1, myeloid related sequence , defensin, alpha 2 , MRS;neutrophil defensin 1;HNP 1;DEF1;DEFA2;Defensin 1;HNP1;HP1;MRS;defensin, alpha 2;OTTHUMP00000196017;myeloid-related sequence;defensin, alpha 1, myeloid-related sequence;HP-1;HNP-1;DEFA1B
Recombinant Proteins
- Mouse
- Human
- Duckbill platypus
- E.coli
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- Mammalian cells
- Yeast
- In Vitro Cell Free System
- His&GST
- Non
- GST
- His
- Myc&DDK
- Twin Strep
- Strep
- His&Fc&Avi
- His&KSI
Involved Pathway
DEFA1 involved in several pathways and played different roles in them. We selected most pathways DEFA1 participated on our site, such as Alpha-defensins,Cellular roles of Anthrax toxin,Defensins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular roles of Anthrax toxin | ANTXR2,ANTXR1 |
| Innate Immune System | ACTR2B,LAT2,MYO1C,SIGIRR,DEFA3,NLRP4C,PANX1,POLR3GLA,CLEC4D,S100B |
| Defensins | DEFB125,DEFB103A,DEFB121,DEFA5,CCR6,DEFB104A,DEFB129,DEFA3,ART1,DEFA6 |
| Alpha-defensins | DEFA3,ART1,DEFA5,DEFA6 |
| Immune System | ARIH1,LILRB2,EVL,MAP3K8,TNIP2,ASB6,RAPGEF3,MGC174152,Mill2,TRIM29 |
Protein Function
DEFA1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFA1 itself. We selected most functions DEFA1 had, and list some proteins which have the same functions with DEFA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
DEFA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFA1.
Dynll1;PFDN1;ZNF16;GSK3B;P/V/C
Resources
Research Area
Inflammatory MediatorsEpithelial Cell Markers and Intracellular Molecules
gamma delta T Cells
Related Services
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References
- Xu, SZ; Lee, SH; et al. Effects of dietary selenium on host response to necrotic enteritis in young broilers. RESEARCH IN VETERINARY SCIENCE 98:66-73(2015).
- Savilahti, EM; Kukkonen, AK; et al. Soluble CD14, alpha-and beta-defensins in breast milk: Association with the emergence of allergy in a high-risk population. INNATE IMMUNITY 21:332-337(2015).
