DDX20

  • Official Full Name

    DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

  • Overview

    The survival of motor neurons (SMN) gene is the disease gene of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The SMN protein is part of a complex containing several proteins, of which one, SIP1 (SMN interacting protein 1), has been characterized so far. The SMN complex is found in both the cytoplasm and in the nucleus, where it is concentrated in bodies called gems. In the cytoplasm, SMN and SIP1 interact with the Sm core proteins of spliceosomal small nuclear ribonucleoproteins (snRNPs), and they play a critical role in snRNP assembly. In the nucleus, SMN is required for premRNA splicing, likely by serving in the regeneration of snRNPs. A DEAD box putative RNA helicase, named Gemin 3 which is another component of the SMN complex, has been identified. Gemin 3 interacts directly with SMN, as well as with SmB, SmD2 and SmD3. Immunolocalization studies using mAbs to Gemin 3 show that it colocalizes with SMN in gems. Gemin 3 binds SMN via its unique COOHterminal domain, and SMN mutations found in some SMA patients strongly reduce this interaction. The presence of a DEAD box motif in Gemin 3 suggests that it may provide the catalytic activity that plays a critical role in the function of the SMN complex on RNPs.

  • Synonyms

    DDX20;DEAD (Asp-Glu-Ala-Asp) box polypeptide 20;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20, 103kD;probable ATP-dependent RNA helicase DDX20;DP103;GEMIN3;gemin-3;DEAD box protein 20;component of gems 3;DEAD-box protein DP103;DEAD box protein DP 103;SMN-interacting protein;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD;DKFZp434H052

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
DDX20-2471H Recombinant Human DDX20 Protein, GST-tagged Wheat Germ Human GST
DDX20-4404M Recombinant Mouse DDX20 Protein Mammalian Cell Mouse His
DDX20-6695Z Recombinant Zebrafish DDX20 Mammalian Cell Zebrafish His
DDX20-7016HCL Recombinant Human DDX20 293 Cell Lysate HEK293 Human Non
DDX20-2266M Recombinant Mouse DDX20 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DDX20-2266M-B Recombinant Mouse DDX20 Protein Pre-coupled Magnetic Beads HEK293 Mouse
DDX20-2472H Recombinant Human DDX20 Protein, MYC/DDK-tagged HEK293T Human Myc&DDK
Ddx20-2501M Recombinant Mouse Ddx20 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
DDX20-2560HF Recombinant Full Length Human DDX20 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 824 amino acids
DDX20-2917H Recombinant Human DDX20 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    DDX20 involved in several pathways and played different roles in them. We selected most pathways DDX20 participated on our site, such as Gene Expression,Metabolism of non-coding RNA,RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport EIF3I,SRRM1,NUP133,EIF2B4,SMN2,THOC3,THOC2,SUMO3B,CLNS1A,TRNT1
    Metabolism of non-coding RNA PEAK1,CLNS1A,WDR77,SNUPN,PRMT5
    mRNA processing BICC1,SUGP2,ZFP830,HNRNPABA,OASL2,LSMD1,HNRNPL,RBM4B,HNRNPD,EIF4E3
    Gene Expression ZNF707,ZNF157,ZNF460,ZNF582,SUZ12A,Txn1,ZFP90,HBXIP,ZNF680,CTGF
    snRNP Assembly WDR77,SNUPN,PEAK1,CLNS1A

    Protein Function

    DDX20 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX20 itself. We selected most functions DDX20 had, and list some proteins which have the same functions with DDX20. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MAP2K6,C2orf51,CCND2,TCEAL5,HNRNPC,EXD1,TPD52L1,MB21D2,FGF3,SYNJ2BP
    protein binding, bridging SLC9A1,STX1A,ST13,FKBP4,TJP2,PPP2R3A,NUFIP1,FSCN3,FSCN2A,VPS18
    DNA binding ARID1A,ZNF559-ZNF177,OLIG2,HOXB8B,ZIC4,LIN54,HER8.2,RABGAP1,SIM1,PAX2
    protein domain specific binding CALM2,CALM3,PLG,TNFAIP1,TJP1,CENPJ,TACC2,ICA1L,IRS2,VCP
    repressing transcription factor binding HDAC4,EIF4E,HHEX,PARK7,HDAC7,MAGEA2B,HMGB1,ARNTL,RELA,TBP
    histone deacetylase binding KPNA2,CDC20,KAT2A,TAL1,SIRT2,BRMS1LA,FOXP3,NACC2,CBX5,YWHAE
    ATP binding DDX17,TRIO,ABCB6,BMPR1B,SCYL3,TOR2A,ATP1A1A.2,MAPK6,ABCD2,PTK7A
    ATP-dependent RNA helicase activity DHX57,SUPV3L1,DHX37,ACTG2,DDX19A,DDX19,DDX39B,FAM120B,DHX36,G3BP1

    Interacting Protein

    DDX20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX20 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX20.

    GEMIN4;SMN1;GEMIN5;MYC;HDAC11;PARP2

    Resources

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