DDX1
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Official Full Name
DEAD (Asp-Glu-Ala-Asp) box helicase 1 -
Overview
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008] -
Synonyms
DDX1;DEAD (Asp-Glu-Ala-Asp) box helicase 1;DBP-RB;UKVH5d;ATP-dependent RNA helicase DDX1;DEAD box-1;DEAD box protein 1;DEAD box polypeptide 1;DEAD box protein retinoblastoma;DEAD (Asp-Glu-Ala-Asp) box polypeptide 1;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Cynomolgus
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- GST
- Non
- N-Twin strep and C-His&Flag
- His&Fc&Avi
- Myc&DDK
- Flag
- His&Myc
Involved Pathway
DDX1 involved in several pathways and played different roles in them. We selected most pathways DDX1 participated on our site, such as Aldosterone synthesis and secretion,Neuronal System,Potassium Channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tandem pore domain potassium channels | KCNK10B,KCNK16,KCNK2,KCNK1B,KCNK2B,KCNK18,KCNK13B,KCNK4,KCNK1,KCNK3A |
| Neuronal System | Apba1,LIN7C,KCNH1A,KCNC2,KCNF1,CACNB4B,SYN2,SLC1A7B,KCNK13B,KCNQ2A |
| Aldosterone synthesis and secretion | AGTR1,ATF6B,AGTR1A,HSD3B1,CAMK1G,GNAS,CAMK1,SCARB1,PRKACB,CACNA1H |
| TWIK-releated acid-sensitive K+ channel (TASK) | KCNK3A |
| Potassium Channels | KCNH1,KCNJ1A.6,KCNA6A,KCNA2,KCNA4,KCNH2,KCNAB2B,KCNK13B,KCNAB2,KCNC1B |
Protein Function
DDX1 has several biochemical functions, for example, S100 protein binding,ion channel activity,open rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX1 itself. We selected most functions DDX1 had, and list some proteins which have the same functions with DDX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S100 protein binding | S100B,ATP2A2,S100A6,FGF1,AHNAK,FGF1A,ANXA11,S100A1,AGER,EZR |
| protein C-terminus binding | HRAS,VIM,SDC1,PEX5,PDZD11,NCL,AGO2,CALCOCO1,MYO1C,SLC9A3R2 |
| open rectifier potassium channel activity | KCNK3,KCNK3A |
| potassium ion leak channel activity | KCNK1A,KCNK15,KCNK18,KCNK2B,KCNK4,KCNK10B,KCNK10,KCNK5,KCNK3,KCNK13B |
| protein homodimerization activity | ANG,TSG101,SLC9A7,EIF2AK3,CR2,TPD52L1,GHR,RRAGA,CBX1,VEGFA |
| protein heterodimerization activity | DRD2,LIFR,BNIP3L,MLXIPL,TFAP2B,GABPB2,MPP7,INHBA,ITGB1A,Defa-rs7 |
| potassium channel activity | KCNA2B,TMEM38B,KCNQ2A,KCNK13B,KCNB2,KCNIP3,KCNQ3,KCNV2,KCNK1A,KCNK3A |
| ion channel activity | CNGA4,CACNA1C,P2RX5,TRPM1B,P2RX3A,CACNA1DA,KCNQ2A,CLCN4-2,CHRNB1L,P2RX4A |
Interacting Protein
DDX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX1.
YWHAZ;RELB;SMAD2;NDRG1;NME7;8-aha-camp;8-aha-omethyladenosine;ssrna_ug
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