DDB2

  • Official Full Name

    damage-specific DNA binding protein 2, 48kDa

  • Overview

    This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]

  • Synonyms

    DDB2;damage-specific DNA binding protein 2, 48kDa;DDBB;UV-DDB2;DNA damage-binding protein 2;UV-DDB 2;DDB p48 subunit;UV-damaged DNA-binding protein 2;damage-specific DNA-binding protein 2;xeroderma pigmentosum group E protein

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Chicken
  • Mouse
  • Zebrafish
  • Wheat Germ
  • Mammalian Cells
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
DDB2-057H Recombinant Human DDB2 Protein, GST-tagged Wheat Germ Human GST Full L. 1-427 a.a.
DDB2-05TH Recombinant Human DDB2 Protein, GST-tagged Wheat Germ Human GST 1 a.a. - 427 a.a.
DDB2-1204R Recombinant Rhesus monkey DDB2 Protein, His-tagged Mammalian Cells Rhesus macaque His
DDB2-28309TH Recombinant Human DDB2 Protein, His-tagged E.coli Human His 1-261 aa
DDB2-3361C Recombinant Chicken DDB2 Mammalian Cells Chicken His
DDB2-452H Recombinant Human DDB2 Protein, His-tagged E.coli Human His Pro166~Met383
Ddb2-453H Recombinant Mouse Ddb2 Protein, His-tagged E.coli Mouse His Lys212~Leu407
DDB2-5371Z Recombinant Zebrafish DDB2 Mammalian Cells Zebrafish His
DDB2-7029HCL Recombinant Human DDB2 293 Cell Lysate HEK293 Human Non
DDB2-1029R Recombinant Rhesus Macaque DDB2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
DDB2-1029R-B Recombinant Rhesus Macaque DDB2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DDB2-1549HF Recombinant Full Length Human DDB2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 427 amino acids
DDB2-1564HF Recombinant Full Length Human DDB2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 427 amino acids
DDB2-1933H Recombinant Human DDB2 Protein (Pro166-Met383), His tagged E.coli Human His Pro166-Met383
DDB2-6874H Recombinant Human DDB2 protein, His-tagged E.coli Human His 1-427aa

    Involved Pathway

    DDB2 involved in several pathways and played different roles in them. We selected most pathways DDB2 participated on our site, such as DNA Damage Recognition in GG-NER,DNA Repair,DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Direct p53 effectors EPHA2,CEBPZ,BNIP3L,HIC1,BCL2L14,DUSP1,ZNF385A,CTSD,NDRG1,TADA2B
    Global Genome Nucleotide Excision Repair (GG-NER) ACTR5,USP45,NFRKB,INO80B,COPS4,ACTL6A,GPS1,CHD1L,COPS5,COPS3
    DNA Damage Recognition in GG-NER PARP1,ACTL6A,CETN2,COPS6,DDB1,INO80C,INO80B,COPS5,COPS3,COPS7A
    Hepatitis B IFNA7,FASLG,PIK3CD,CREB3L3,STAT5B,PRKCG,CASP10,IFIH1,DDX3X,NFKBIA
    DNA damage response RAD17,HUS1B,CHEK2,CDK5,GADD45A,RAD9A,RAD1,GADD45G,TLK2
    DNA Repair CHD1L,USP43A,TOPBP1,EYA2,ALKBH2,PARP1,MCRS1,KIAA0101,ASCC1,INO80C
    Formation of Incision Complex in GG-NER USP45,DDB1,PARP2,CHD1L,RNF111,CETN2,PIAS3
    Dual Incision in GG-NER PARP2,DDB1,CHD1L

    Protein Function

    DDB2 has several biochemical functions, for example, DNA binding,contributes_to damaged DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDB2 itself. We selected most functions DDB2 had, and list some proteins which have the same functions with DDB2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ABI2,PPP1R9A,CCDC94,HIF1AN,NCL,FCN1,HYPM,PDP1,GBAS,DEDD2
    DNA binding SMUG1,SMAD9,DTD1,ETV5,ARID5B,TLX3B,LBX1,RPL7,H3F3B.1,ZNF710
    contributes_to ubiquitin-protein transferase activity KEAP1B,KLHL41,KLHL24A,DBN1,KLHL31,KEAP1A,KLHL14,BACH1A,KLHL15,KLHL10
    contributes_to damaged DNA binding DDB1,CUL4B,NBN

    Interacting Protein

    DDB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDB2.

    DDB1;COPS5;CUL4A;Ddb1;DDA1;E2F1;CUL4B;COPS6;GPS1

    Resources

    Research Area

    Nucleotide Excision Repair/Transcription Coupled Repair

    References

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