DCTN2
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Official Full Name
dynactin 2 (p50) -
Overview
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. -
Synonyms
DCTN2;dynactin 2 (p50);dynactin subunit 2;DCTN 50;RBP50;p50 dynamitin;dynactin complex 50 kD subunit;dynactin complex 50 kDa subunit;50 kD dynein-associated polypeptide;50 kDa dynein-associated polypeptide;DCTN50;DYNAMITIN
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- Flag
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DCTN2 involved in several pathways and played different roles in them. We selected most pathways DCTN2 participated on our site, such as Adaptive Immune System,Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | GORASP1,MAD2L2,TEX15,CDCA5,DPF1,INCENP,ORC4L,ANKLE2,CENPI,BORA |
| Assembly of the primary cilium | KIF3B,RP2,NINL,ARF4,EXOC3,DYNLL2,AKAP9,SSNA1,RAB3IP,CEP290 |
| Anchoring of the basal body to the plasma membrane | RPGRIP1L,HAUS2,NINL,MAPRE1A,SDCCAG8,TMEM216,CEP89,CEP70,RAB3IP,TCTN1 |
| G2/M Transition | MAPRE1A,CKAP5,CCP110,NUMA1,CEP78,CDK11A,LIN9,TUBG1,DYNC1I2,CEP72 |
| Huntingtons disease | GRM5,TP53,PPARGC1A,COX7A2L,NDUFS4,DNAIC2,PLCB3,NDUFA6,Casp3,DNAL4 |
| Cell Cycle, Mitotic | USO1,PIANP,CEP135,APITD1,SMC2,STIL,NIPBL,TUBGCP5,MYBL2,NINL |
| Adaptive Immune System | LTN1,TRIM50,UBA5,CTSE,UBE2E3,ARF1,PIK3AP1,ASB10,CD300LD,BLMH |
| Centrosome maturation | CLASP1A,CEP72,CKAP5,ODF2B,CEP76,NUMA1,DYNC1H1,TUBB4B,TUBG1,TUBG2 |
Protein Function
DCTN2 has several biochemical functions, for example, motor activity,protein binding,spectrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCTN2 itself. We selected most functions DCTN2 had, and list some proteins which have the same functions with DCTN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| spectrin binding | ADD2,MYO10,EPB41,SLC26A5,ANK1,DYNC1I1,UNC13A,STX4A,KIF3A,ADD1 |
| protein binding | EHD2,TRAPPC5,DAP3,KIR2DL1,RTN2,ZFP143,INADL,IFNA4,FZR1,FDX1L |
| motor activity | MYO10,MYH6,DYNLL1,VMHC,KIF18B,MYO1H,MYH9,MYH1,MYO6A,MYO5C |
Interacting Protein
DCTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCTN2.
CCDC172;HAUS1;KIFC3;BLOC1S6;GADD45A;Dctn1;IKBKE;EGFR;GNAO1;p29991-pro_0000308465
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