DAO
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Official Full Name
D-amino-acid oxidase -
Overview
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. -
Synonyms
DAO;D-amino-acid oxidase;DAMOX;DAAO;DAO1;EC 1.4.3.3;MGC35381;OXDA;OXDA_HUMAN;D-amino acid oxidase
Recombinant Proteins
- Human
- Pig
- Rat
- Mouse
- Cynomolgus
- E.coli
- Porcine Kidney
- Mammalian Cell
- Wheat Germ
- HEK293
- Insect Cell
- Yeast
- In Vitro Cell Free System
- E. coli
- GST
- Non
- His
- His&SUMO
- His&Myc
- His&Fc&Avi
Involved Pathway
DAO involved in several pathways and played different roles in them. We selected most pathways DAO participated on our site, such as Arginine and proline metabolism,Biosynthesis of antibiotics,D-Arginine and D-ornithine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of amino acids and derivatives | CKMB,NQO1,CRYM,CKMT2A,DIO2,GLS2B,CDO1,AHCY,SLC6A8,ACMSD |
| D-Arginine and D-ornithine metabolism | DAO.3,DAO.2,DAO.1,DAO1 |
| Glyoxylate metabolism and glycine degradation | AGXT,DAO1 |
| Arginine and proline metabolism | P4HA1A,CKM,P4HA1,GOT2A,SAT1,AOC1,CKMT1,MAOB,CNDP1,CNDP2 |
| Glycine, serine and threonine metabolism | GLYCTK,BPGM,AOC2,CBSA,TDH,AMT,GAMT,SARDH,AGXTA,DLDH |
| Metabolic pathways | HSD17B3,SPS2,ASPA,PLA2G6,MAT2AA,FBP1A,TYR,MGAT4B,GMPPB,GCDHA |
| Metabolism | ARL2,PDK3B,COX14,PEMT,CYP2K6,TACO1,COX5B,CYP4F12,ABHD4,CDIPT |
| Biosynthesis of antibiotics | NME6,LDHAL6B,ADH5,DLAT,GALM,SDSL,DLST,GPR19,PAICS,ANI_1_2390104 |
Protein Function
DAO has several biochemical functions, for example, D-amino-acid oxidase activity,FAD binding,cofactor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAO itself. We selected most functions DAO had, and list some proteins which have the same functions with DAO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FAD binding | ACOX1,AIFM1,DAO.3,AGPS,DERL3,CRY2,KMO,CYB5R3,MICAL1,DAO.1 |
| cofactor binding | PAH,HIF1AN,HACL1,UROS,ASNS,PHYH,DDO,ACLYA,TKT,ME3 |
| protein binding | BCOR,SPAST,STX6,JUNB,S100A1,CARD9,GGNBP2,PML,U2AF1,NDC80 |
| receptor binding | RIPK2,CD2,GNB2L1,EPHX2,CRTAM,CCL13,HSD17B4,CCL17,HILPDA,FGF12B |
| protein dimerization activity | HER1,FAP,ANO4,EBF2,HIF1AL2,TFAP2A,CREB3,AIFM1,GGN,ACTN2 |
| D-amino-acid oxidase activity | DAO.2,DAO.3,DAO1,DAO.1 |
Interacting Protein
DAO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAO here. Most of them are supplied by our site. Hope this information will be useful for your research of DAO.
PRKAB2;EP300
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References
- Nishimura, Y; Tanaka, H; et al. Immunohistochemical localization of D-serine dehydratase in chicken tissues. ACTA HISTOCHEMICA 116:702-707(2014).
- Schwelberger, HG; Feurle, J; et al. New tools for studying old questions: antibodies for human diamine oxidase. JOURNAL OF NEURAL TRANSMISSION 120:1019-1026(2013).
