Cyp11a1
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Official Full Name
cytochrome P450, family 11, subfamily A, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008] -
Synonyms
CYP11A1;cytochrome P450, family 11, subfamily A, polypeptide 1;CYP11A;CYPXIA1;P450SCC;cholesterol side-chain cleavage enzyme, mitochondrial;steroid 20-22-lyase;cytochrome P450 11A1;cytochrome P450(scc);cytochrome P450C11A1;cholesterol 20-22 desmolase;cholesterol monooxygenase (side-chain cleaving);cytochrome P450, subfamily XIA (cholesterol side chain cleavage)
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- Cattle
- Pig
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- HEK293T
- Mamanlian cells
- In Vitro Cell Free System
- His
- Myc&DDK
- GST
- His&T7
- Non
- His&Fc&Avi
- His&SUMO
- MBP&His&Avi
- Flag
Involved Pathway
Cyp11a1 involved in several pathways and played different roles in them. We selected most pathways Cyp11a1 participated on our site, such as Aldosterone synthesis and secretion,Biological oxidations,Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cyp11a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Corticotropin-releasing hormone | IVL,CRHR1,TCF4,JUND,CRHR2,TBX19,CRHBP,ADRBK2,CYP11B1,PARP1 |
| Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) | FDX1,FDXR,FDX1L |
| Endogenous sterols | CYP27A1,CYP21A2,CYP17A1,POMCB,CYP19A1,CYP8B2,CYP1B1,CYP11B1,CYP51A1,FDX1L |
| Disease | CDK8,KERA,SUPT4H1,JAG2,CCR5,TNKS,OPN1LW,CDC37,GPC5,RDBP |
| Diseases of metabolism | FDX1,EPM2A,MMAA,SFTPC,MTRR,MMADHC,GYG2,AMN,FDXR,GYG1 |
| Aldosterone synthesis and secretion | CREB3L4,CYP21A1,Adcy4,LIPE,CREB3L1,CREB5,HSD3B6,PLCB4,CREB3L3,ADCY3 |
| Biological oxidations | GSTK1,CYP2C19,CYP1A1,CYP2K16,AS3MT,CYP2F1,SULT1ST5,CYP2C18,BPNT1,AKR1A1 |
| Cytochrome P450 - arranged by substrate type | CYP2Y3,CYP3C4,CYP2K8,CYP2J2,FAM84B,FDXR,CYP2C9,CYP2A7,CYP27A1,CYP2B6 |
Protein Function
Cyp11a1 has several biochemical functions, for example, cholesterol binding,cholesterol monooxygenase (side-chain-cleaving) activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Cyp11a1 itself. We selected most functions Cyp11a1 had, and list some proteins which have the same functions with Cyp11a1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | CYP11B2,CYP2E1,MICAL2,COQ6,CYP11B1,MTRR,NDOR1,CYP4F11,POR,CYP4F18 |
| cholesterol binding | STARD6,APOC3,CETP,PTCH1,SOAT1,OSBPL8,TSPO2,APOA1A,APOA4A,CAV1 |
| iron ion binding | TMLHE,CYP4V2,SC5DL,CYP46A1,PDF,CYP2S1,HBA-X,MFI2,CH25HL2,AOX4 |
| heme binding | PTGS2,CYB5R4,CYP2A13,CYP8B3,CYP4V7,CYP3A7,PTGS1,CYP26B1,CYP2A6,CYP51 |
Interacting Protein
Cyp11a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cyp11a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cyp11a1.
SMAD9;SMAD3;SMAD2;A2M
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References
- Guo, JJ; Li, XW; et al. The increased number of Leydig cells by di(2-ethylhexyl) phthalate comes from the differentiation of stem cells into Leydig cell lineage in the adult rat testis. TOXICOLOGY 306:9-15(2013).
- Li, MH; Wu, FR; et al. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. BIOLOGY OF REPRODUCTION 86:-(2012).
