CYP4F3

  • Official Full Name

    cytochrome P450, family 4, subfamily F, polypeptide 3

  • Overview

    This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene.

  • Synonyms

    CYP4F3;cytochrome P450, family 4, subfamily F, polypeptide 3;cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase) , LTB4H;leukotriene-B(4) omega-hydroxylase 2;CYP4F;CP4F3_HUMAN;CPF3;CYPIVF3;Cytochrome P450 4F3;Cytochrome P450 LTB omega;Cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase);Cytochrome P450-LTB-omega;Leukotriene B(4) 20 monooxygenase;Leukotriene B(4) omega hydroxylase;leukotriene B4 omega hydroxylase;Leukotriene-B(4) 20-monooxygenase 2;leukotriene-B4 20-monooxygenase;LTB4H;cytochrome P-450;cytochrome P450, subfamily IVF, polypeptide 3

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Mus musculus
  • Wheat Germ
  • Mammalian Cell
  • E.coli
  • E.coli expression system
  • GST
  • Non
  • His
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP4F3-2285H Recombinant Human CYP4F3 Protein, GST-tagged Wheat Germ Human GST
CYP4F3-28191TH Recombinant Human CYP4F3 Wheat Germ Human Non 99 amino acids
CYP4F3-5626Z Recombinant Zebrafish CYP4F3 Mammalian Cell Zebrafish His
CYP4F3-21H Active Recombinant Human CYP4F3 Protein E.coli Human
CYP4F3-86H Active Recombinant Human CYP4F3 Protein E.coli Human
RFL23043RF Recombinant Full Length Rat Leukotriene-B(4) Omega-Hydroxylase 2(Cyp4F3) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length (1-524)
RFL23570HF Recombinant Full Length Human Leukotriene-B(4) Omega-Hydroxylase 2(Cyp4F3) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-520)
RFL5894MF Recombinant Full Length Mouse Leukotriene-B(4) Omega-Hydroxylase 2(Cyp4F3) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-524)

    Involved Pathway

    CYP4F3 involved in several pathways and played different roles in them. We selected most pathways CYP4F3 participated on our site, such as Arachidonic acid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism PLA2G4C,PLA2G2F,MAPKAPK2B,CYP1A2,CYP1B1,CYP4A12A,ALOX12E,LTC4S,PTGDSA,CYP2B19
    Metabolic pathways PLD1,NANSA,ADO,CMASA,MTR,GNS,PIGS,CYP19A1A,PLA2G12B,CMAS

    Protein Function

    CYP4F3 has several biochemical functions, for example, alpha-tocopherol omega-hydroxylase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F3 itself. We selected most functions CYP4F3 had, and list some proteins which have the same functions with CYP4F3. You can find most of the proteins on our site.

    Function Related Protein
    alpha-tocopherol omega-hydroxylase activity CYP4F18,CYP4F14,CYP4F2
    leukotriene-B4 20-monooxygenase activity CYP4F2,CYP4F12,CYP4F14,CYP4A10,CYP4A11,CYP4F18
    monooxygenase activity CYP1A4,CYP3C1,CYP2X7,MICAL2B,FAM84B,CYP46A1.1,CYP2AA7,CYP2AD3,BCMO1,CYP2A12
    iron ion binding CYP2D10,CYP46A1.1,CYP1A2,CYP11B1,POR,CYP2A7,CYP2K22,TMLHE,CYP2X10.2,CYP2C39
    heme binding HRG,CYGB,CYP27B1,CYP4F11,SRC,CYP2K19,CYP2Y3,CYB5B,CYP2K22,HBAA

    Interacting Protein

    CYP4F3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F3.

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