CYP1A2
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Official Full Name
cytochrome P450, family 1, subfamily A, polypeptide 2 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. -
Synonyms
CYP1A2;cytochrome P450, family 1, subfamily A, polypeptide 2;CP12;P3-450;P450(PA);cytochrome P450 1A2;P450 form 4;cytochrome P450 4;cytochrome P(3)450;cytochrome P450-P3;dioxin-inducible P3-450;microsomal monooxygenase;xenobiotic monooxygenase;aryl hydrocarbon hydroxylase;flavoprotein-linked monooxygenase;cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
Recombinant Proteins
- Human
- Rat
- Dog
- Pig
- Mouse
- E.coli
- Insect Cell
- HEK293
- Mammalian Cell
- Wheat Germ
- P.pastoris
- In Vitro Cell Free System
- HEK293T
- Protein Conjugation
- Mamanlian cells
- His
- Non
- Myc&DDK
- GST
- His&GST
- His&Fc&Avi
- Flag
Involved Pathway
CYP1A2 involved in several pathways and played different roles in them. We selected most pathways CYP1A2 participated on our site, such as Aflatoxin B1 metabolism,Aflatoxin activation and detoxification,AhR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | TBXAS1,CYP4F22,GPX1A,ALOX5,ALOX5AP,AKR1C21,PTGES3,CYP4F2,PLA2G4C,PTGIS |
| Arylamine metabolism | NAT2 |
| Aflatoxin B1 metabolism | FAM84B,CYP2A13,CYP3A4,PRKRA |
| Aflatoxin activation and detoxification | GGT6,FAM84B,DPEP1,DPEP2,CYP3A5,CYP3A4,PRKRA,CYP3C1,ACY3,CYP3C4 |
| AhR pathway | CYP1A1,AIP,CDKN1B,PTGES3,CYP1B1,EGFR,AHRR,JUND,FLG,CDC37 |
| Biological oxidations | COMT,DPEP2,CYP2U1,ADH1B,CYP2AD3,AKR1A1,UGT1B4,UGT1B2,CYP2C18,SULT1C4 |
| Caffeine metabolism | PNAT10,XDH,Nat3,NAT,PNAT3,CYP2A6,UOX,NAT1,NAT2 |
Protein Function
CYP1A2 has several biochemical functions, for example, aromatase activity,caffeine oxidase activity,demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1A2 itself. We selected most functions CYP1A2 had, and list some proteins which have the same functions with CYP1A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2AA2,CYP2Y3,CYP2D10,CYP2X9,CYP2U1,CYP2K6,CYP2A7,CYP2B6,CYP1B1,CYP2AD6 |
| electron carrier activity | GLRX2,ACADM,SDHD,NDUFS1,AOX1,PTGESL,IDH3B,NOX4,ACAD9,GLDC |
| monooxygenase activity | CYP2AD3,CYP46A1.4,BCO1,CYP4F18,CYP2AA2,CYP2C18,CYP4F3,YWHABL,CYP2D6,CYP3A7 |
| oxidoreductase activity | CYP2V1,AKR1C6,RDH1,CYP2AA4,ALOX12E,CYP8B3,HADHAA,CYP3A4,SARDH,CHML |
| demethylase activity | CYP1A1,CYP3A41A,ALKBH4,KDM1A,CYP3A41B |
| iron ion binding | CYP1B1,CYP7A1A,CYP2C38,HBBE3,HBAD,TPH1,CYP17A1,CYP2S1,CYP2C39,CYP26A1 |
| heme binding | PGRMC2,CYP2P6,CYP2AA8,CYP1A,HRG-1,CYP2X9,CYP4A10,CYP3A4,DUOX2,HBAE3 |
| aromatase activity | CYP2C54,CYP2C37,CYP2J2,CYP19A1,CYP2A13,CYP2U1,CYP2B19,CYP2C38,FAM84B,CYP2C9 |
| enzyme binding | TH,PPARG,SLC27A2,USP22,MLEC,PICK1,HDAC10,TSPYL1,UBE4B,BACE1 |
Interacting Protein
CYP1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1A2.
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References
- von der Heyde, S; Wagner, S; et al. mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer. PLOS ONE 10:-(2015).
- Czerwinski, M; Kazmi, F; et al. Anti-CD28 Monoclonal Antibody-Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In Vitro. DRUG METABOLISM AND DISPOSITION 43:42-52(2015).
