CXCL6

  • Official Full Name

    Chemokine (C-X-C motif) ligand 6

  • Overview

    Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.

  • Synonyms

    GCP2;Chemokine (C-X-C motif) ligand 6;CXCL6

Recombinant Proteins

  • Human
  • CHO
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • E. coli
  • Fc
  • His
  • T7
  • Non
  • GST

    Involved Pathway

    CXCL6 involved in several pathways and played different roles in them. We selected most pathways CXCL6 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL21R,TGFB3,KITA,CXCL10,BMPR2A,CRFB16,PDGFA,TNFSF10,TGFBR2,CXCR4B
    Chemokine signaling pathway GSK3B,PIK3CA,Cxcl15,MAPK3,Ccl12,CCR5,CCR1L1,CXCL1,CCL1,Ccl21a
    Rheumatoid arthritis ATP6V0E1,ATP6V1E2,MMP1A,ITGB2L,CD86,VEGFA,ATP6V1C1,Ccl12,ICAM1,CXCL5
    Pertussis CASP1,MAPK13,IL12A,Il23a; Il12b,C1R,FOS,IL23,C4BPA,C4A,PYCARD

    Protein Function

    CXCL6 has several biochemical functions, for example, CXCR chemokine receptor binding,chemokine activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL6 itself. We selected most functions CXCL6 had, and list some proteins which have the same functions with CXCL6. You can find most of the proteins on our site.

    Function Related Protein
    chemokine activity CCL25B,CCL34A.4,Ccl21c,Cxcl15,CCL25,CCL3,PF4,IL8L2,CXCL16,CXCL2
    CXCR chemokine receptor binding PPBP,CXCL5,CXCL2,CXCL12B,PF4V1,CXCL12,ITCH,AMCF-II,CXCL3,CXCL20
    heparin binding PF4V1,LIPH,NRP2,PTPRF,WISP3,UBE4A,SLIT1,CXCL13,CCL15,WISP1B

    Interacting Protein

    CXCL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL6.

    SSX2IP

    Resources

    Gene Families

    What Is Chemokine
    Cytokines

    Research Area

    CXC Chemokines

    References

    • Tian, H; Huang, PX; et al. HIF-1 alpha Plays a Role in the Chemotactic Migration of Hepatocarcinoma Cells Through the Modulation of CXCL6 Expression. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 34:1536-1546(2014).
    • Besnard, AG; Struyf, S; et al. CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model. JOURNAL OF LEUKOCYTE BIOLOGY 94:1317-1323(2013).

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