CUX1
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Official Full Name
cut-like homeobox 1 -
Overview
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
CUX1;cut-like homeobox 1;cut (Drosophila) like 1 (CCAAT displacement protein) , cut like 1, CCAAT displacement protein (Drosophila) , CUTL1;protein CASP;CASP;CDP;CDP/Cut;CDP/Cux;CDP1;Clox;CUT;CUX;Cux/CDP;golgi integral membrane protein 6;GO
Recombinant Proteins
- Human
- Chicken
- Mouse
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293T
- HEK293
- E.coli expression system
- GST
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CUX1-11709H | Recombinant Human CUX1, GST-tagged | E.coli | Human | GST | C-term-341a.a. | |
| CUX1-3332H | Recombinant Human CUX1 protein, His-tagged | E.coli | Human | His | 1-341 aa | |
| CUX1-2139H | Recombinant Human CUX1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CUX1-5492C | Recombinant Chicken CUX1 | Mammalian Cell | Chicken | His |
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| CUX1-424HCL | Recombinant Human CUX1 cell lysate | Human | Non |
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| Cux1-2382M | Recombinant Mouse Cux1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CUX1-2756H | Recombinant Human CUX1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| CUX1-301226H | Recombinant Human CUX1 protein, GST-tagged | E.coli | Human | GST | Met1-Ser341 |
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| CUX1-3381H | Recombinant Human CUX1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| RFL26395MF | Recombinant Full Length Mouse Protein Casp(Cux1) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-678) |
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Involved Pathway
CUX1 involved in several pathways and played different roles in them. We selected most pathways CUX1 participated on our site, such as Disease,Diseases of signal transduction,FGFR1 mutant receptor activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FGFR1 mutant receptor activation | LRRFIP1,TRIM24,FGFR1OP,CPSF6,MYO18A,FGFR1OP2 |
| Signaling by FGFR in disease | CPSF6,LRRFIP1,MYO18A,TRIM24,FGFR1OP2 |
| Disease | STX1B,PSTPIP2,NPM1,HDAC5,AP2B1,FKBP1A,PACS1,CHMP4B,CCDC59,KREMEN1 |
| Signaling by FGFR1 fusion mutants | MYO18A,FGFR1OP2,TRIM24,CPSF6 |
| Signaling by FGFR1 in disease | MYO18A,TRIM24,CPSF6,FGFR1OP2 |
| Diseases of signal transduction | CPSF6,OPN1MW,KREMEN2,HDAC5,CTBP2,RBP1,CDK8,TRAT1,CDC37,DERL2 |
Protein Function
CUX1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by CUX1 itself. We selected most functions CUX1 had, and list some proteins which have the same functions with CUX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | OSR2,HOXD9,BCL6AB,ATF6,PRDM15,GATA1A,ZFP551,FOXD3,HSF2,ZBTB4 |
| chromatin binding | NCOA1,PKN1,HMGXB4A,ORC1L,MPO,DNAJC2,CREB3,YBX1,FOXC1A,CITED2 |
| protein binding, bridging | STX1A,LOR,EVPL,FGB,ADAP2,CAV1,VPS18,MMS19,SH2D1B,DDX20 |
| sequence-specific DNA binding | NR2F1B,OTPA,DRGX,PAX7,NKX2.9,NR2F6A,DLX3,HOXB9A,DMRT2A,FOXA3 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | FOXH1,SIX3,POU4F1,PBX3,MEOX2,SIX6,ARID3B,NFE2L2,ZEB2,NFE2L1 |
Interacting Protein
CUX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CUX1.
RB1;BIN1;CA12;RECQL5;MAX;q7cl32_yerpe;narX;ELAC2
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References
- Gan, XT; Zhao, GJ; et al. Identification of Fat Mass and Obesity Associated (FTO) Protein Expression in Cardiomyocytes: Regulation by Leptin and Its Contribution to Leptin-Induced Hypertrophy. PLOS ONE 8:-(2013).
- Ikeda, T; Kumagai, E; et al. Soluble CD26/Dipeptidyl Peptidase IV Enhances the Transcription of IL-6 and TNF-alpha in THP-1 Cells and Monocytes. PLOS ONE 8:-(2013).
