CSPG4
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Official Full Name
chondroitin sulfate proteoglycan 4 -
Overview
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008] -
Synonyms
CSPG4;chondroitin sulfate proteoglycan 4;NG2;MCSP;MCSPG;MSK16;HMW-MAA;MEL-CSPG;chondroitin sulfate proteoglycan NG2;melanoma chondroitin sulfate proteoglycan;melanoma-associated chondroitin sulfate proteoglycan;chondroitin sulfate proteoglycan 4 (melanoma-associated)
Recombinant Proteins
- Human
- Cynomolgus
- Rat
- Mammalian cells
- C-His
- E.coli
- Mammalian Cell
- HEK293
- Human cells
- His
- His&GST
- His&Fc&Avi
- Flag
- His&Myc
Involved Pathway
CSPG4 involved in several pathways and played different roles in them. We selected most pathways CSPG4 participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis,CS/DS degradation,Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSPG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defective B4GALT7 causes EDS, progeroid type | CSPG5,DCN,NCAN,GPC6,BGN,BCAN,AGRN,VCAN,GPC5 |
| Chondroitin sulfate/dermatan sulfate metabolism | BCAN,VCANB,CSPG5B,BGNA,DSEL,UST,DCN,CHST9,GPC5A,B3GAT2 |
| chondroitin sulfate biosynthesis | VCAN,BGNA,BCAN,UST,CSPG5B,B3GAT2,CSPG5,DCN,NCAN,VCANB |
| A tetrasaccharide linker sequence is required for GAG synthesis | B4GALT7,BGN,GPC1A,NCAN,VCAN,Gpc2,CSPG5B,GPC5,VCANB,GPC5A |
| Defective CHST14 causes EDS, musculocontractural type | DCN,CSPG5,BCAN,BGN |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | BCAN,CSPG5,GPC5,VCAN,GPC6,BGN,DCN,AGRN,NCAN |
| CS/DS degradation | VCAN,CSPG5B,DCN,VCANB,NCAN,BGN,BGNB,CSPG5,BCAN,BGNA |
| Defective B3GAT3 causes JDSSDHD | NCAN,GPC5,VCAN,AGRN,BCAN,CSPG5,BGN,DCN,GPC6 |
Protein Function
CSPG4 has several biochemical functions, for example, protein kinase binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSPG4 itself. We selected most functions CSPG4 had, and list some proteins which have the same functions with CSPG4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | CHRNA7,ADIPOR1,CCNL1B,CDKN2B,LLGL1,GRIN2A,FAM83A,H2AFY,CD4,RCC2 |
| signal transducer activity | IL15RA,HTR1AA,RGS6,GNA11B,PLCH2,OPRD1A,TAAR10B,PLCG2,GNG11,SH2B3 |
Interacting Protein
CSPG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSPG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSPG4.
ganglioside_gm1;ATF7IP;Gspt1;SORT1;Tbc1d7;ZNF644
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References
- Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).
- Warta, R; Herold-Mende, C; et al. Reduced promoter methylation and increased expression of CSPG4 negatively influences survival of HNSCC patients. INTERNATIONAL JOURNAL OF CANCER 135:2727-2734(2014).
