CRYGC
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Official Full Name
crystallin, gamma C -
Overview
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. -
Synonyms
CRYGC;crystallin, gamma C;CRYG3;gamma-crystallin C;CATARACT, VARIABLE ZONULAR PULVERULENT;CCL;CRGC_HUMAN;CRYG 3;Cryg 5;Cryg;Crystallin gamma 3;Crystallin gamma C;Gamma C crystallin;Gamma crystallin 2 1;Gamma crystallin 3;Gamma crystallin C;Gamma-C-crystallin;Gamma-crystallin 2-1;Gamma-crystallin 3;Gammab cry;Len;OTTHUMP00000163869;crystallin, gamma-3
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- E. coli
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CRYGC involved in several pathways and played different roles in them. We selected most pathways CRYGC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYGC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CRYGC has several biochemical functions, for example, protein binding,structural constituent of eye lens. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYGC itself. We selected most functions CRYGC had, and list some proteins which have the same functions with CRYGC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of eye lens | LIM2.5,LIM2.3,CRYGS,CRYBA1,CRYGN2,CRYAA,ASL1,CRYBA4,LIM2.4,CRYABA |
| protein binding | MAPK13,GRAMD3,FAM206A,TFRC,ZNF398,KDM2B,PDE4C,MYPOP,SLC5A1,DYRK2 |
Interacting Protein
CRYGC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYGC here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYGC.
CRYAA;CRYAB;CRYBB2
Resources
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References
- Moreno-Mendieta, SA; Guillen, D; et al. A novel antigen-carrier system: The Mycobacterium tuberculosis Acr protein carried by raw starch microparticles. INTERNATIONAL JOURNAL OF PHARMACEUTICS 474:241-248(2014).
- Dalakas, MC; et al. Mechanistic Effects of IVIg in Neuroinflammatory Diseases: Conclusions Based on Clinicopathologic Correlations. JOURNAL OF CLINICAL IMMUNOLOGY 34:S120-S126(2014).
