CRTC3
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Official Full Name
CREB regulated transcription coactivator 3 -
Overview
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent;gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein;encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A;translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein,;has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that;encode different protein isoforms. -
Synonyms
CRTC3;CREB regulated transcription coactivator 3;CREB-regulated transcription coactivator 3;FLJ21868;TORC-3;transducer of CREB protein 3;transducer of regulated CREB protein 3;transducer of regulated cAMP response element-binding protein 3;transdu
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CRTC3-1114H | Recombinant Human CRTC3 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Phe103 |
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| CRTC3-32H | Recombinant Human CRTC3 protein, GST-tagged | Wheat Germ | Human | GST | 176-274 a.a. |
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| CRTC3-3928M | Recombinant Mouse CRTC3 Protein | Mammalian Cells | Mouse | His |
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| CRTC3-1992M | Recombinant Mouse CRTC3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&His&Fc |
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| CRTC3-1992M-B | Recombinant Mouse CRTC3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CRTC3-2207H | Recombinant Human CRTC3 Protein (Met1-Phe103), N-GST tagged | E.coli | Human | GST | Met1-Phe103 |
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Involved Pathway
CRTC3 involved in several pathways and played different roles in them. We selected most pathways CRTC3 participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRTC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | EGR2,NFKB1,TGFBR1,NFATC4,WNT5B,HLA-A,HLA-DQA2,H2-Q10,PPP3CB,LCK |
Protein Function
CRTC3 has several biochemical functions, for example, cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRTC3 itself. We selected most functions CRTC3 had, and list some proteins which have the same functions with CRTC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cAMP response element binding protein binding | ATF2,CRTC1A,CRTC2,CRTC1,DDIT3,DAPK3,CREB3,KCNA3,CREM |
Interacting Protein
CRTC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRTC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRTC3.
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References
- Chatel, G; Desai, SH; et al. Domain topology of nucleoporin Nup98 within the nuclear pore complex. JOURNAL OF STRUCTURAL BIOLOGY 177:81-89(2012).
- Puthiyaveetil, AG; Heid, B; et al. A NUP98-HOXD13 leukemic fusion gene leads to impaired class switch recombination and antibody production. EXPERIMENTAL HEMATOLOGY 40:622-633(2012).
