CRTAM
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Official Full Name
cytotoxic and regulatory T cell molecule -
Overview
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and;encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 (PubMed 18329370)). -
Synonyms
CRTAM;cytotoxic and regulatory T cell molecule;cytotoxic and regulatory T-cell molecule;CD355;class I MHC restricted T cell associated molecule;OTTHUMP00000231739;class-I MHC-restricted T cell associated molecule;class-I MHC-restricted T-cell-associated molecule
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Canine
- Rhesus macaque
- Chicken
- E.coli
- HEK293
- Mammalian cells
- C-His
- Wheat Germ
- Mammalian Cell
- Insect Cell
- Human Cell
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Fc
- Non
- hIgG4
- His&Fc&Avi
Involved Pathway
CRTAM involved in several pathways and played different roles in them. We selected most pathways CRTAM participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRTAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | CD200R2,TREM1,CLEC2D,OSCAR,CD300LD,AF251705,KLRG1,CD226,LILRB3,CXADR |
| Immune System | RNF123,PVRL2L,PANX1,CD96,CTSH,EVL,KIR3DS1,AP1S1,LGALS3,ASB4 |
| Adaptive Immune System | WSB1,CTSB,CHUK,ASB14,HLA-DQB2,AKR1C1,KIF5A,KIF18A,DCTN6,LAIR2 |
Protein Function
CRTAM has several biochemical functions, for example, cell adhesion molecule binding,protein homodimerization activity,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRTAM itself. We selected most functions CRTAM had, and list some proteins which have the same functions with CRTAM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | CDH5,NUDT7,Icosl,PTPRD,TENC1,CSK,YES1,NPPC,PLXNC1,IDE |
| protein homodimerization activity | CARD9,DCK,FAP,ERBB3,GDNFA,S100A5,MIXL1,HLA-G,CER1,ERBB4 |
| cell adhesion molecule binding | NLGN3,CPE,LILRB2,ITGB2,DSG2,CADM2,PVRL2,ITGB7,PVR,ITGAL |
| receptor activity | PAQR5,RNF139,DERL1,IGF2R,GRIA3B,ADIPOR1,LRRN2,PVRL3B,PVRL3,GRIK5 |
Interacting Protein
CRTAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRTAM here. Most of them are supplied by our site. Hope this information will be useful for your research of CRTAM.
Resources
Research Area
Natural Killer Cell (NK Cell)Nectin and Nectin-like Ligand/Receptor Co-Signaling Molecules
Co-stimulatory Molecules
Related Services
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References
- Matesanz-Isabel, J; Sintes, J; et al. New B-cell CD molecules. IMMUNOLOGY LETTERS 134:104-112(2011).
- Zechmann, M; Reese, S; et al. Chicken CRTAM Binds Nectin-Like 2 Ligand and Is Upregulated on CD8(+) alpha beta and gamma delta T Lymphocytes with Different Kinetics. PLOS ONE 8:-(2013).
