CRTAC1
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Official Full Name
cartilage acidic protein 1 -
Overview
This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. -
Synonyms
CRTAC1;cartilage acidic protein 1;ASPIC1;CEP 68;FLJ10320;68 kDa chondrocyte expressed protein;68 kDa chondrocyte-expressed protein;Acidic secreted protein in cartilage;ASPIC;Cartilage acidic protein 1 precursor;CEP-68;CEP68;CRAC1_HUMAN;Protein CRTAC1-B;W307;chondrocyte expressed protein 68 kDa CEP-68
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CRTAC1 involved in several pathways and played different roles in them. We selected most pathways CRTAC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRTAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CRTAC1 has several biochemical functions, for example, calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRTAC1 itself. We selected most functions CRTAC1 had, and list some proteins which have the same functions with CRTAC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DNAJC7,ZNF664-FAM101A,MB21D2,PPIF,HIST1H1C,ALOX12,OLFM2,EFNA1,BAD,JAG1 |
| calcium ion binding | FKBP10B,PCDH1G31,STIM1,TPO,CHP1,PCDH1GB2,ANXA1B,PCDH2AB7,ITSN2,SVEP1 |
Interacting Protein
CRTAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRTAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRTAC1.
AQP1;MAPRE2;MORN4
Resources
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References
- Russinoff, S; Miran, S; et al. Osteosarcoma Cells Differentiate into Phenotypes from all Three Dermal Layers. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH 469:2895-2904(2011).
- Kariya, H; Yoshihara, Y; et al. Carboxymethyl-chitin promotes chondrogenesis by inducing the production of growth factors from immune cells. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 94A:1034-1041(2010).
