CPT1A
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Official Full Name
carnitine palmitoyltransferase 1A (liver) -
Overview
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CPT1A;carnitine palmitoyltransferase 1A (liver);CPT1;carnitine O-palmitoyltransferase 1, liver isoform;CPT1 L;L CPT1;CPT I;CPTI-L;carnitine palmitoyltransferase I, liver;carnitine O-palmitoyltransferase I, liver isoform;CPT1-L;L-CPT1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- Mus musculus
- Horse
- E.coli
- Wheat Germ
- HEK293T
- Mammalian Cell
- HEK293
- Human Cell
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Myc&DDK
- His&GST
- Non
- Flag
- His&Fc&Avi
Involved Pathway
CPT1A involved in several pathways and played different roles in them. We selected most pathways CPT1A participated on our site, such as AMPK signaling,AMPK signaling pathway,Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPT1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipocytokine signaling pathway | ACSL1,NFKBIB,RXRB,ADIPOR2,PRKAG2,RELA,AKT2,RXRBA,PRKCQ,MAPK9 |
| FOXA2 and FOXA3 transcription factor networks | UCP2,CEBPA,FOXA1,CPT1B,CPT1C,DLK1,FOXF1,KCNJ11,TTR |
| Fatty acid degradation | ALDH2.2,GCDHA,ADH6,ALDH3A2,CPT1C,ACSL4A,ACSBG1,ADH1B,ACADVL,ACSL4B |
| AMPK signaling pathway | CAMKK2,PPP2CA,CREB3L3,PRKAG3,PIK3R1,CPT1C,SCD5,ACACA,PPARGC1A,RAB10 |
| Circadian Clock | CARM1,RAI1,CRY2,NRIP1,NAMPT,HELZ2,CRY1,DBP,CSNK1E |
| AMPK signaling | INS-IGF2,ADRa1A,CPT1B,EEF2,EIF4EBP1,SLC2A4RG,CPT1C,CAMKK2,CDKN1A,PPARGC1B |
| Fatty Acid Beta Oxidation | CHKB,DECR1,CPT2,CPT1B,SLC25A20,ECI1,CRAT |
| Fatty acid metabolism | EHHADH,CPT2,HSD17B12B,PTPLA,ACSBG2,FADS1,ACSL4B,SCD,ACAA1,FASN |
Protein Function
CPT1A has several biochemical functions, for example, carnitine O-palmitoyltransferase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPT1A itself. We selected most functions CPT1A had, and list some proteins which have the same functions with CPT1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | AGXT2L2,LEPR,UAP1,NLRC4,SOD1,SUN2,GRIN3A,GDF5,ERBB2,CLPP |
| carnitine O-palmitoyltransferase activity | CPT2,CPT1B,CPT1C |
Interacting Protein
CPT1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPT1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CPT1A.
ESR2;CACYBP;CLIC1;HSPA5;CYBA;NR4A1;q81ye8_bacan;KBTBD7;leuD;carA;NPDC1;15-deoxy-delta(12,14;ssrna_ug;E2F3
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