CORIN
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Official Full Name
Corin, serine peptidase -
Overview
Corin, also known as Atrial Natriuretic Peptide-converting enzyme, is a 1042 amino acid single-pass type II membrane protein that is found on the cell membrane. It is highly expressed in the heart and heart myocytes. Corin is a serine-type endopeptidase that is involved in atrial natriuretic peptide hormone processing. It converts, through proteolytic cleavage, the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. Corin may also process pro-NPPB the B-type natriuretic peptide. Enzyme regulation is inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine. Corin is N-glycosylated, which is required for processing and activation. It is consists of a disulfide bond that links the N- terminal propeptide and the activated Corin protease fragment. Corin is activated through proteolytic processing by a trypsin-like protease: cleaved into an N-terminal propeptide and an activated Corin protease fragment. It is initially named Corin due to its abundant expression in the heart. -
Synonyms
ATC2;CRN;Lrp4;PEE5;TMPRSS10;atrial natriuretic peptide-converting enzyme;heart-specific serine proteinase ATC2;pro-ANP-convertase;pro-ANP-converting enzyme;transmembrane protease serine 10
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- E. coli
- His&GST
- His
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
CORIN involved in several pathways and played different roles in them. We selected most pathways CORIN participated on our site, such as Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CORIN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Myometrial Relaxation and Contraction Pathways | PKIB,GUCA2A,IGFBP4,IGFBP5,RGS19,CNN2,CRHR1,RAMP1,RXFP2,MYLK2 |
Protein Function
CORIN has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CORIN itself. We selected most functions CORIN had, and list some proteins which have the same functions with CORIN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | F9A,RHBDD3,CFB,PCSK6,PCSK7,PLAUA,DPP4,PRSS12,C1RL,TMPRSS4B |
Interacting Protein
CORIN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CORIN here. Most of them are supplied by our site. Hope this information will be useful for your research of CORIN.
Resources
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References
- Foo, JYY; Wan, YX; et al. Circulating Fragments of N-Terminal Pro-B-Type Natriuretic Peptides in Plasma of Heart Failure Patients. CLINICAL CHEMISTRY 59:1523-1531(2013).
- Peleg, A; Jaffe, AS; et al. Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood. CLINICA CHIMICA ACTA 409:85-89(2009).
