CLCA2
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Official Full Name
chloride channel accessory 2 -
Overview
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. -
Synonyms
CLCA2;chloride channel accessory 2;chloride channel regulator 2 , chloride channel, calcium activated, family member 2;calcium-activated chloride channel regulator 2;CLCRG2;35 kDa form;CaCC-3;CaCC3;Calcium-activated chloride channel family member 2;Calcium-activated chloride channel protein 3;Calcium-activated chloride channel-2;Chloride channel, calcium activated, family member 2;CLCA2_HUMAN;hCaCC-3;hCLCA2;OTTHUMP00000011911;chloride channel regulator 2;CLCA family member 2, chloride channel regulator;calcium-activa;CACC
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- HEK293
- HEK293T
- Mamanlian cells
- GST
- His
- Myc&DDK
- Non
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLCA2-11274H | Recombinant Human CLCA2, GST-tagged | E.coli | Human | GST | 595-901a.a. | |
| CLCA2-1123H | Recombinant Human CLCA2 Protein, His-tagged | E.coli | Human | His | 595-901 aa | |
| CLCA2-1409H | Recombinant Human CLCA2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CLCA2-168H | Recombinant Human CLCA2 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| CLCA2-7478HCL | Recombinant Human CLCA2 293 Cell Lysate | HEK293 | Human | Non |
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| Clca2-2176M | Recombinant Mouse Clca2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CLCA2-8091HFL | Recombinant Full Length Human CLCA2 protein, Flag-tagged | Mamanlian cells | Human | Flag | Full L. |
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Involved Pathway
CLCA2 involved in several pathways and played different roles in them. We selected most pathways CLCA2 participated on our site, such as Renin secretion,Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renin secretion | GNAI1,LOC100328615,PDE3A,PRKACA,ITPR1,Ren1,PTGER4,PRKACB,CLCA3,GNAI2 |
| Pancreatic secretion | PLA2G5,ATP1B2,CELA2B,ATP2A1,ATP2A3,KCNMA1,Slc4a2,RAB27B,CLCA1,Adcy4 |
Protein Function
CLCA2 has several biochemical functions, for example, chloride channel activity,intracellular calcium activated chloride channel activity,ligand-gated ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCA2 itself. We selected most functions CLCA2 had, and list some proteins which have the same functions with CLCA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| intracellular calcium activated chloride channel activity | ANO9,ANO7,CLCA4,ANO2,TTYH3,ANO4,NMUR2,CLCA1,ANO6,ANO8 |
| ligand-gated ion channel activity | GABRB1,CHRNB4,CLCA5,CHRNA5,Chrng,P2RX2,TRPA1A,CHRNB2,ANXA6,ZACN |
| metal ion binding | ZBTB8B,F13A1,TRIM67,ZDHHC16B,KDM2BA,ZNF484,ZFP319,RASA3,BTR18,ZFP551 |
| chloride channel activity | GABRA5,CLIC4,GABRA6,CLIC5B,CFTR,CLCA4,SLC26A6L,SLC26A3.2,SLC26A9,ANO2 |
| metallopeptidase activity | MMP23BB,ADAMTS1,ADAM21,CHMP1A,ANPEP,C6AST4,MMP13A,ADAMTS16,PAPPA,PAPLNB |
Interacting Protein
CLCA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCA2.
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References
- Gonzalez-Silva, C; Vera, J; et al. Ca2+-Activated Cl- Channels of the ClCa Family Express in the Cilia of a Subset of Rat Olfactory Sensory Neurons. PLOS ONE 8:-(2013).
- Kim, KX; Marcus, DC; et al. Inward-rectifier chloride currents in Reissner's membrane epithelial cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394:434-438(2010).
