CIDEC
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Official Full Name
cell death-inducing DFFA-like effector c -
Overview
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified. -
Synonyms
cell death-inducing DFFA-like effector c;CIDEC;FSP27;CIDE-3;FLJ20871;cell death activator CIDE-3;OTTHUMP00000158645;OTTHUMP00000207602;fat specific protein 27;Cell Death Inducing DFFA Like Effector C;Cell death inducing DFFA like effector protein C;Cell death-inducing DFFA-like effector protein C;CIDE3;CIDEC_HUMAN;Fat-specific protein FSP27 homolog;CIDEX
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&GST
- His&Fc&Avi
- His&T7
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CIDEC-1365H | Recombinant Human CIDEC Protein, GST-tagged | Wheat Germ | Human | GST |
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| CIDEC-1414R | Recombinant Rat CIDEC Protein | Mammalian Cell | Rat | His |
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| CIDEC-27245TH | Recombinant Human CIDEC | Wheat Germ | Human | Non | 238 amino acids |
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| CIDEC-3473M | Recombinant Mouse CIDEC Protein | Mammalian Cell | Mouse | His |
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| CIDEC-413H | Recombinant Human CIDEC Protein, GST-His-tagged | E.coli | Human | His&GST |
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| CIDEC-5055C | Recombinant Chicken CIDEC | Mammalian Cell | Chicken | His |
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| CIDEC-7495HCL | Recombinant Human CIDEC 293 Cell Lysate | HEK293 | Human | Non |
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| CIDEC-1072R | Recombinant Rat CIDEC Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CIDEC-1072R-B | Recombinant Rat CIDEC Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CIDEC-1447H | Recombinant Human CIDEC protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Gln251 |
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| Cidec-1448R | Recombinant Rat Cidec protein, His & T7-tagged | E.coli | Rat | His&T7 | Met1~Gln221 |
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| CIDEC-1692M | Recombinant Mouse CIDEC Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CIDEC-1692M-B | Recombinant Mouse CIDEC Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CIDEC-1850HF | Recombinant Full Length Human CIDEC Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 238 amino acids |
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| CIDEC-2203H | Recombinant Human CIDEC Protein (Met1-Gln238), N-His tagged | E.coli | Human | His | Met1-Gln238 |
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| CIDEC-2204H | Recombinant Human CIDEC Protein (Met1-Gln241), His tagged | E.coli | Human | His | Met1-Gln241 |
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| CIDEC-4688H | Recombinant Human CIDEC protein, GST-tagged | E.coli | Human | GST | 1-238aa |
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| CIDEC-81HF | Recombinant Full Length Human CIDEC Protein | In Vitro Cell Free System | Human | Full L. 238 amino acids |
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Involved Pathway
CIDEC involved in several pathways and played different roles in them. We selected most pathways CIDEC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CIDEC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CIDEC has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by CIDEC itself. We selected most functions CIDEC had, and list some proteins which have the same functions with CIDEC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | BTBD16,DISP2,EMILIN3,GM13057,ANKRD12,GOLIM4B,PHF16,HIST1H2BD,MAGEA5,LRRC9 |
Interacting Protein
CIDEC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CIDEC here. Most of them are supplied by our site. Hope this information will be useful for your research of CIDEC.
Resources
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References
- Tanaka, N; Takahashi, S; et al. Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice. JOURNAL OF BIOLOGICAL CHEMISTRY 290:3092-3105(2015).
- Zhou, LK; Park, SY; et al. Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice. Nature Communications 6:-(2015).
