CHST15
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Official Full Name
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -
Overview
Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix;and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in;which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts;as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been;identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling;receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
CHST15;carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15;carbohydrate sulfotransferase 15;B cell RAG associated protein;BRAG;GALNAC4S 6ST;KIAA0598;N acetylgalactosamine 4 sulfate 6 O sulfotransferase;hBRAG;B-cell RAG-associat
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Human Cell
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CHST15 involved in several pathways and played different roles in them. We selected most pathways CHST15 participated on our site, such as Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | CHPF,CSGALNACT1,CHPF2,XYLT1,CSGALNACT2,B3GAT3,CHST7,CHST14,DSE,UST |
Protein Function
CHST15 has several biochemical functions, for example, 3-phosphoadenosine 5-phosphosulfate binding,N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST15 itself. We selected most functions CHST15 had, and list some proteins which have the same functions with CHST15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-phosphoadenosine 5-phosphosulfate binding | HS3ST5,CHST12,GAL3ST4,ENPP1 |
| N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity | CHST11 |
Interacting Protein
CHST15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHST15 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHST15.
SLC43A3;CASC3;FARS2;CCNB1;HIVEP1;CANX;EIF5A;RABL6;TJAP1;PHF5A;ERC1;NDUFAF2;LPGAT1;SLC35E1;ILKAP;SLC25A19;PLEKHG1;KLHDC2;CEPT1
Resources
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References
- Iida, J; Dorchak, J; et al. Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth. EXPERIMENTAL CELL RESEARCH 330:358-370(2015).
