CHRM2
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Official Full Name
cholinergic receptor, muscarinic 2 -
Overview
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. -
Synonyms
CHRM2;cholinergic receptor, muscarinic 2;HM2;FLJ43243;MGC120006;MGC120007;muscarinic acetylcholine receptor M2;7TM receptor;OTTHUMP00000208393;OTTHUMP00000208394;OTTHUMP00000208395;OTTHUMP00000208396;muscarinic M2 receptor;cholinergic receptor, muscarinic 2, isoform a;Muscarinic receptors;mAChRs
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Pan troglodytes
- Mus musculus
- Bovine
- Sus scrofa (Pig)
- HEK293
- Wheat Germ
- Mammalian Cell
- E.coli
- In Vitro Cell Free System
- E.coli expression system
- Flag
- Non
- GST
- His
- His&Fc&Avi
- His&Flag
Involved Pathway
CHRM2 involved in several pathways and played different roles in them. We selected most pathways CHRM2 participated on our site, such as Amine ligand-binding receptors,Arf6 trafficking events,Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | CACNA1SB,VDAC2,PHKB,PHKG2,DRD1A,ADRA1BB,ATP2B1,TNNC1B,ORAI1B,CALM1 |
| Amine ligand-binding receptors | ADRA2B,ADRB3,ADRB2,ADRA1B,ADRA2C,ADRA1D,CHRM4,DRD3,CHRM5,DRD4 |
| Arf6 trafficking events | SCAMP2,EXOC1,EXOC3,CTNNA1,JUP,EXOC5,SPAG9,CLTC,CTNND1,CPE |
| Class A/1 (Rhodopsin-like receptors) | CCL19A.2,LPAR2B,MLN,GPR55A,TRH,GPR65,OPN4B,PTGDR2,EDN2,CCR6 |
| GPCR downstream signaling | FPR-RS4,OXGR1,CGA,ADCYAP1R1,AKAP13,NMUR1,TAS2R16,MCF2L,GHRH,ITSN1 |
| Calcium Regulation in the Cardiac Cell | RGS19,ADRa1A,CX55.5,CX44.1,GJA4,RGS10,ADRB3,RGS14,GJB3,CX27.5 |
| Cholinergic synapse | CHRM5,ITPR3,PLCB2,CHRNA4,PRKCB,CHAT,AKT2,GNG8,PIK3CA,PIK3R5 |
| G alpha (i) signalling events | PYY,NMU,CXCL11.8,RGS19,LPAR5A,GPR55,LPAR2B,CCR1,APPB,HCAR1-2 |
Protein Function
CHRM2 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM2 itself. We selected most functions CHRM2 had, and list some proteins which have the same functions with CHRM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| drug binding | CYP2C9,NR1I2,CHRNB2,CHRM3,PDE2A,PIGC,CHRNB4,CHRNA2,DAAM2,HTR1B |
| G-protein coupled acetylcholine receptor activity | CHRM5,CHRM2A,CHRM5A,CHRM4,CHRM5B,CHRM3,CHRM1 |
Interacting Protein
CHRM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM2.
GPRASP1;GPRASP2;af-dx 384;methoctramine;Lamp1;Arrb2
Resources
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References
- Riese, H; Munoz, LM; et al. Identifying Genetic Variants for Heart Rate Variability in the Acetylcholine Pathway. PLOS ONE 9:-(2014).
- Srivastava, P; Yadav, RS; et al. Unraveling the mechanism of neuroprotection of curcumin in arsenic induced cholinergic dysfunctions in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY 279:428-440(2014).
