CHMP4A
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Official Full Name
charged multivesicular body protein 4A -
Overview
CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are;components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of;surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and;cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and;regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)). -
Synonyms
CHMP4A;charged multivesicular body protein 4A;C14orf123, chromatin modifying protein 4A , chromosome 14 open reading frame 123;HSPC134;VPS32A;C14orf123;Chromatin modifying protein 4a;SHAX2;SNF7 homolog associated with Alix-2;Snf7 homologue associated with Alix 2;vacuolar protein sorting-associated protein 32-1;SNF7;CHMP4;CHMP4B;SNF7-1;VPS32-1
Recombinant Proteins
- Human
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- HEK293T
- GST
- Non
- His
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHMP4A-11186H | Recombinant Human CHMP4A, GST-tagged | E.coli | Human | GST | C-term-95a.a. | |
| CHMP4A-1251H | Recombinant Human CHMP4A Protein | E.coli | Human | Non |
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| CHMP4A-1252H | Recombinant Human CHMP4A Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CHMP4A-1376H | Recombinant Human Charged Multivesicular Body Protein 4A, His-tagged | E.coli | Human | His |
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| CHMP4A-351HCL | Recombinant Human CHMP4A cell lysate | Human | Non |
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| CHMP4A-3207HF | Recombinant Full Length Human CHMP4A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 265 amino acids |
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| CHMP4A-3233H | Recombinant Human CHMP4A Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| CHMP4A-6331H | Recombinant Human CHMP4A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
CHMP4A involved in several pathways and played different roles in them. We selected most pathways CHMP4A participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHMP4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | CHMP5,IL2RB,ARFGAP1,ADRBK2,FGFR4,HSP70L,LDLRAP1B,VPS24,ARAP1,PIP5K1BB |
Protein Function
CHMP4A has several biochemical functions, for example, ATPase binding,identical protein binding,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHMP4A itself. We selected most functions CHMP4A had, and list some proteins which have the same functions with CHMP4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF426,ZFP36,GLDN,LDHA,BRCC3,PSMA7,PIP5K1A,GPN3,UTP11L,FRAG1 |
| lipid binding | PITPNC1,PSAP,PFN3,AP2M1,SH3GL2,APOA1B,ACBD6,ALOX8,SH3GL3,UNC119.1 |
| identical protein binding | CCT7,EIF2AK3,INS2,IK,IL12B,FRS3,SDCBP,AMOTL2,SH3GL2,PPPDE2 |
| protein homodimerization activity | AGR2,S100B,ZHX3,TPD52L1,TBX1,KLRB1B,LHPP,CADM4,BCL11A,FOXP3 |
| ATPase binding | NUFIP1,EZR,ANK2,PIH1D1,ATP6V0A2B,PEX26,RAB4A,SELS,NHP2L1,PGR |
Interacting Protein
CHMP4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHMP4A here. Most of them are supplied by our site. Hope this information will be useful for your research of CHMP4A.
SYT17;USP54;PDCD6IP;ETS1;STAMBP;GAK;Ptpn23;TFG;Chmp4b
Resources
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References
- Barlin, JN; Jelinic, P; et al. Validated gene targets associated with curatively treated advanced serous ovarian carcinoma. GYNECOLOGIC ONCOLOGY 128:512-517(2013).
- Shi, TP; Dong, YQ; et al. High-throughput screening identifies CHMP4A associated with hypoxia-inducible factor 1. LIFE SCIENCES 87:604-608(2010).
