CFI

  • Official Full Name

    complement factor I

  • Overview

    Complement factor I, also known as C3B/C4B inactivator, is a protein that in humans is encoded by the CFI gene. Complement Factor I (fI) is a protein of the complement system, first isolated in 1966 in guinea pig serum that regulates complement activation by cleaving cell-bound or fluid phase C3b and C4b.

  • Synonyms

    CFI;complement factor I;I factor (complement) , IF;C3b INA;C3b inactivator;FI;KAF;Konglutinogen activating factor;C3b-inactivator;C3B/C4B inactivator;complement component I;light chain of factor I;Konglutinogen-activating factor;complement fa

Recombinant Proteins

  • Mouse
  • Human
  • Rat
  • Chicken
  • C-His
  • Mammalian Cell
  • E.coli
  • HEK293
  • E. coli
  • Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II)
  • Mammalian cells
  • Insect Cell
  • HEK293T
  • Mammalian cell
  • His
  • His&GST
  • Non
  • His&Fc&Avi
  • His&Myc
  • Flag
  • N-His-GST&C-Myc
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
Cfi-1408M Recombinant Mouse Cfi protein, His-tagged C-His Mouse Arg19-Val603
CFI-1560H Recombinant Human CFI protein, His-tagged C-His Human Lys19-Val583
CFI-1355R Recombinant Rat CFI Protein Mammalian Cell Rat His
CFI-2054H Recombinant Human CFI protein, His & GST-tagged E.coli Human His&GST Leu28~Gly243
Cfi-2055M Recombinant Mouse Cfi protein, His-tagged E.coli Mouse His Arg358~Val603
CFI-290H Recombinant Human CFI protein, His-tagged E.coli Human His Ile340~Val583
CFI-3349M Recombinant Mouse CFI Protein Mammalian Cell Mouse His
CFI-4700C Recombinant Chicken CFI Mammalian Cell Chicken His
CFI-9302H Recombinant Human CFI protein, His-tagged E.coli Human His Leu28~Gly243
CFI-7556HCL Recombinant Human CFI 293 Cell Lysate HEK293 Human Non
CFI-1013R Recombinant Rat CFI Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CFI-1013R-B Recombinant Rat CFI Protein Pre-coupled Magnetic Beads HEK293 Rat
CFI-1051H Recombinant Human CFI Protein (Lys19-Ile335), N-His tagged E.coli Human His Lys19-Ile335
CFI-1052H Recombinant Human CFI protein, His-tagged E. coli Human His 19-583aa
CFI-1053H Recombinant Human CFI protein, His-tagged HEK293 Human His 19-583aa
CFI-105H Active Native Human Factor I Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II) Human Non
Cfi-1070M Recombinant Mouse Cfi protein, His&Myc-tagged HEK293 Mouse His&Myc 19-603aa
CFI-1531HFL Recombinant Full Length Human CFI Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
CFI-1613M Recombinant Mouse CFI Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CFI-1613M-B Recombinant Mouse CFI Protein Pre-coupled Magnetic Beads HEK293 Mouse
Cfi-2210M Recombinant Mouse Cfi protein, His&Myc-tagged Insect Cell Mouse His&Myc 19-603aa
Cfi-2211R Recombinant Rat Cfi protein, His&Myc-tagged Insect Cell Rat His&Myc 19-604aa
CFI-2741H Recombinant Human CFI protein(239-316aa), His-GST&Myc-tagged E. coli Human N-His-GST&C-Myc 239-316aa
Cfi-4998R Recombinant Rat Cfi protein, His&Myc-tagged HEK293 Rat His&Myc 19-604aa
CFI-585H Recombinant Human CFI Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CFI-585H-B Recombinant Human CFI Protein Pre-coupled Magnetic Beads HEK293 Human
Cfi-880M Recombinant Mouse Cfi Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
Cfi-938M Recombinant Mouse Cfi protein, His&Myc-tagged Mammalian cell Mouse His&Myc 19-603aa

    Involved Pathway

    CFI involved in several pathways and played different roles in them. We selected most pathways CFI participated on our site, such as Complement and coagulation cascades,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Staphylococcus aureus infection HLA-DMB,SELPLG,Itgam&Itgb2,PTAFR,FPR1,FCGR2B,HLA-DMA,C1QA,FPR3,C2
    Complement and coagulation cascades Hc,C3,CFH,MASP2,C3AR1,CFD,MBL1,F11,FGA,C8G

    Protein Function

    CFI has several biochemical functions, for example, metal ion binding,protein binding,scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CFI itself. We selected most functions CFI had, and list some proteins which have the same functions with CFI. You can find most of the proteins on our site.

    Function Related Protein
    scavenger receptor activity CCBP2,CD163,CD6,PRSS7,LOXL2,LGALS3BPB,VTNA,SCARA3,LGALS3BPA,PRG4A
    protein binding CHRM3,TSPAN12,TINAGL1,AP3M1,TTN,SEMA4A,SEC22C,MYL2,SDC2,PTMA
    metal ion binding HDHD1A,ELMSAN1A,TREX1,RNF11A,CYP2AD3,POMT2,ZBTB2,ZFP473,S100T,AGO2
    serine-type endopeptidase activity KLKB1,KLK1B3,C1RA,FURINB,TPP1,PCSK5,MCPT9,KLK13,CLPP,TMPRSS5

    Interacting Protein

    CFI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFI here. Most of them are supplied by our site. Hope this information will be useful for your research of CFI.

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    Resources

    References

    • Szarvas, N; Szilagyi, A; et al. First-line therapy in atypical hemolytic uremic syndrome: consideration on infants with a poor prognosis. ITALIAN JOURNAL OF PEDIATRICS 40:-(2014).
    • Ardissino, G; Testa, S; et al. Discontinuation of Eculizumab Maintenance Treatment for Atypical Hemolytic Uremic Syndrome: A Report of 10 Cases. AMERICAN JOURNAL OF KIDNEY DISEASES 64:633-637(2014).

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