CES2
-
Official Full Name
carboxylesterase 2 -
Overview
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010] -
Synonyms
CES2;carboxylesterase 2;iCE;CE-2;PCE-2;CES2A1;cocaine esterase;hCE-2;carboxylesterase 2 (intestine, liver);methylumbelliferyl-acetate deacetylase 2;intestinal carboxylesterase;liver carboxylesterase-2
Recombinant Proteins
- Human
- Zebrafish
- Rat
- BTI Insect Cell
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cell
- Human Cell
- Mamanlian cells
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- Non
- His
- Myc&DDK
- GST
- Flag
- His&Fc&Avi
Involved Pathway
CES2 involved in several pathways and played different roles in them. We selected most pathways CES2 participated on our site, such as Drug metabolism - other enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CES2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - other enzymes | DPYS,UCK2A,UGT1A2,UGT1AB,CYP2A6,XDH,UGT1A3,UGT1A1,UGT1A6A,UPP2 |
Protein Function
CES2 has several biochemical functions, for example, carboxylic ester hydrolase activity,methylumbelliferyl-acetate deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CES2 itself. We selected most functions CES2 had, and list some proteins which have the same functions with CES2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carboxylic ester hydrolase activity | ESD,Ces2c,ACOT8,BAAT,ACOT2,CES3A,ACOT12,LIPH,ABHD4,NOTUM1A |
| methylumbelliferyl-acetate deacetylase activity | CES1,ESD |
Interacting Protein
CES2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CES2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CES2.
ispH;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
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